BAIT
LRRC4C
6430556C10Rik, NGL-1
leucine rich repeat containing 4C
GO Process (1)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
PLCB1
3110043I21Rik, AI132408, Plcb, mKIAA0581, RP23-418D21.3
phospholipase C, beta 1
GO Process (36)
GO Function (9)
GO Component (8)
Gene Ontology Biological Process
- G-protein coupled acetylcholine receptor signaling pathway [IMP]
- G2/M transition of mitotic cell cycle [IDA, NAS]
- activation of meiosis involved in egg activation [IDA]
- brain development [NAS]
- cell adhesion [IC]
- cerebral cortex development [IMP]
- erythrocyte differentiation [TAS]
- fat cell differentiation [IDA]
- glutamate receptor signaling pathway [IMP]
- insulin receptor signaling pathway [TAS]
- insulin-like growth factor receptor signaling pathway [IDA]
- interleukin-1-mediated signaling pathway [ISO]
- interleukin-12-mediated signaling pathway [ISO]
- interleukin-15-mediated signaling pathway [ISO]
- mRNA processing [TAS]
- macrophage differentiation [NAS]
- memory [IMP]
- negative regulation of monocyte extravasation [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- oocyte maturation [NAS]
- positive regulation of CD24 biosynthetic process [IDA]
- positive regulation of G1/S transition of mitotic cell cycle [IDA]
- positive regulation of GTPase activity [ISO]
- positive regulation of JNK cascade [ISO]
- positive regulation of acrosome reaction [IMP]
- positive regulation of developmental growth [IMP]
- positive regulation of embryonic development [IMP]
- positive regulation of interleukin-12 production [IMP]
- positive regulation of myoblast differentiation [IDA]
- positive regulation of sodium:proton antiporter activity [NAS]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of G-protein coupled receptor protein signaling pathway [IMP]
- regulation of fertilization [IMP]
- response to monosaccharide [ISO]
- response to peptide hormone [ISO]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.
There are hundreds of risk genes associated with autism spectrum disorder (ASD), but signaling networks at the protein level remain unexplored. We use neuron-specific proximity-labeling proteomics (BioID2) to identify protein-protein interaction (PPI) networks for 41 ASD risk genes. Neuron-specific PPI networks, including synaptic transmission proteins, are disrupted by de novo missense variants. The PPI network map reveals convergent pathways, including ... [more]
Cell Rep Nov. 22, 2022; 41(8);111678 [Pubmed: 36417873]
Quantitative Score
- 0.331121514 [Relative Biotinylation Score]
Throughput
- High Throughput
Additional Notes
- BioID experiment
- The scores are relative biotinylation enrichment scores (calculated as a percentage of the abundance fold change of the highest biotinylated prey protein)
- The statistical cut-offs for the prey proteins are based on adjusted t-test p-value and significance B scores of less than 0.05, by comparing average abundances of prey proteins between the Bait-BioID samples and the luciferase-BioID control
Curated By
- BioGRID