BAIT
NRXN1
1700062G21Rik, 9330127H16Rik, A230068P09Rik, mKIAA0578
neurexin I
GO Process (22)
GO Function (7)
GO Component (5)
Gene Ontology Biological Process
- adult behavior [IMP, ISO]
- gephyrin clustering [IDA]
- learning [IMP, ISO]
- neuroligin clustering [IDA]
- neuromuscular process controlling balance [IMP]
- neurotransmitter secretion [IGI, TAS]
- positive regulation of excitatory postsynaptic membrane potential [IMP]
- positive regulation of synapse assembly [IGI]
- positive regulation of synapse maturation [IDA]
- positive regulation of synaptic transmission, glutamatergic [IMP]
- postsynaptic density protein 95 clustering [IDA]
- postsynaptic membrane assembly [IDA]
- prepulse inhibition [IMP]
- protein heterotetramerization [ISO]
- regulation of grooming behavior [IMP]
- regulation of insulin secretion involved in cellular response to glucose stimulus [IMP]
- social behavior [ISO]
- synapse assembly [IGI]
- synaptic transmission [IGI]
- vesicle docking involved in exocytosis [ISO]
- vocal learning [ISO]
- vocalization behavior [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
HSPB1
27kDa, Hsp25
heat shock protein 1
GO Process (15)
GO Function (6)
GO Component (10)
Gene Ontology Biological Process
- cellular response to vascular endothelial growth factor stimulus [ISO]
- intracellular signal transduction [ISO]
- negative regulation of apoptotic signaling pathway [IDA]
- negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [IDA]
- negative regulation of protein kinase activity [IDA]
- negative regulation of protein serine/threonine kinase activity [IDA]
- platelet aggregation [ISO]
- positive regulation of angiogenesis [ISO]
- positive regulation of blood vessel endothelial cell migration [ISO]
- positive regulation of endothelial cell chemotaxis [ISO]
- positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway [ISO]
- positive regulation of interleukin-1 beta production [IDA]
- positive regulation of tumor necrosis factor biosynthetic process [IDA]
- regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- response to unfolded protein [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.
There are hundreds of risk genes associated with autism spectrum disorder (ASD), but signaling networks at the protein level remain unexplored. We use neuron-specific proximity-labeling proteomics (BioID2) to identify protein-protein interaction (PPI) networks for 41 ASD risk genes. Neuron-specific PPI networks, including synaptic transmission proteins, are disrupted by de novo missense variants. The PPI network map reveals convergent pathways, including ... [more]
Cell Rep Nov. 22, 2022; 41(8);111678 [Pubmed: 36417873]
Quantitative Score
- 0.167323237 [Relative Biotinylation Score]
Throughput
- High Throughput
Additional Notes
- BioID experiment
- The scores are relative biotinylation enrichment scores (calculated as a percentage of the abundance fold change of the highest biotinylated prey protein)
- The statistical cut-offs for the prey proteins are based on adjusted t-test p-value and significance B scores of less than 0.05, by comparing average abundances of prey proteins between the Bait-BioID samples and the luciferase-BioID control
Curated By
- BioGRID