BAIT
NTRK2
GP145-TrkB/GP95-TrkB, Tkrb, trk-B, trkB
neurotrophic tyrosine kinase, receptor, type 2
GO Process (37)
GO Function (8)
GO Component (23)
Gene Ontology Biological Process
- brain-derived neurotrophic factor receptor signaling pathway [IDA, ISO]
- calcium-mediated signaling using intracellular calcium source [IMP]
- central nervous system neuron development [IMP]
- cerebral cortex development [IMP]
- feeding behavior [IMP]
- glutamate secretion [IPI]
- learning [IMP]
- long-term memory [ISO]
- long-term synaptic potentiation [IMP]
- mechanoreceptor differentiation [IMP]
- negative regulation of anoikis [IDA]
- negative regulation of neuron apoptotic process [ISO]
- neuromuscular junction development [IMP]
- neuron differentiation [IMP]
- neuron migration [IMP]
- neurotrophin signaling pathway [IDA, ISO]
- oligodendrocyte differentiation [IMP]
- peptidyl-tyrosine phosphorylation [IDA, ISO]
- peripheral nervous system neuron development [IMP]
- positive regulation of MAPK cascade [ISO]
- positive regulation of axonogenesis [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of gene expression [IMP]
- positive regulation of glucocorticoid receptor signaling pathway [ISO]
- positive regulation of neuron projection development [IDA]
- positive regulation of peptidyl-serine phosphorylation [IMP]
- positive regulation of phosphatidylinositol 3-kinase signaling [ISO]
- positive regulation of synaptic transmission, glutamatergic [ISO]
- protein autophosphorylation [ISO]
- regulation of MAPK cascade [ISO]
- regulation of Rac GTPase activity [IDA]
- regulation of dendrite development [ISO]
- regulation of metabolic process [IMP]
- regulation of neurotransmitter secretion [ISO]
- regulation of protein kinase B signaling [IMP]
- retinal rod cell development [IMP]
- vasculogenesis [IMP]
Gene Ontology Molecular Function- brain-derived neurotrophic factor binding [IDA, ISO]
- brain-derived neurotrophic factor-activated receptor activity [IDA, ISO]
- ephrin receptor binding [ISO]
- neurotrophin binding [IDA, ISO]
- neurotrophin receptor activity [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- transmembrane receptor protein tyrosine kinase activity [ISO]
- brain-derived neurotrophic factor binding [IDA, ISO]
- brain-derived neurotrophic factor-activated receptor activity [IDA, ISO]
- ephrin receptor binding [ISO]
- neurotrophin binding [IDA, ISO]
- neurotrophin receptor activity [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- transmembrane receptor protein tyrosine kinase activity [ISO]
Gene Ontology Cellular Component
- axon [ISO]
- axon terminus [ISO]
- cell [IPI]
- cell surface [ISO]
- cytoplasm [ISO]
- cytosol [IDA]
- dendrite [ISO]
- dendritic spine [ISO]
- endosome [IDA]
- excitatory synapse [ISO]
- growth cone [ISO]
- integral component of plasma membrane [ISO]
- intracellular [IMP]
- neuronal cell body [ISO]
- neuronal postsynaptic density [IDA]
- perikaryon [ISO]
- plasma membrane [IDA, ISO]
- postsynaptic density [ISO]
- postsynaptic membrane [IDA]
- presynaptic active zone [ISO]
- receptor complex [ISO]
- rough endoplasmic reticulum [ISO]
- terminal bouton [IDA]
Mus musculus
PREY
DVL1
Dvl, mKIAA4029, RP23-242K15.15-003
dishevelled, dsh homolog 1 (Drosophila)
GO Process (34)
GO Function (6)
GO Component (14)
Gene Ontology Biological Process
- Wnt signaling pathway [IGI, NAS, TAS]
- Wnt signaling pathway, planar cell polarity pathway [IDA, IGI, IMP, ISO]
- axon extension [IDA]
- axon guidance [IDA]
- axonogenesis [IDA]
- canonical Wnt signaling pathway [IDA, IGI, IMP, ISO]
- cochlea morphogenesis [IGI]
- collateral sprouting [IDA]
- convergent extension involved in neural plate elongation [IGI]
- convergent extension involved in organogenesis [IGI, IMP]
- cytoplasmic microtubule organization [IDA, IGI]
- dendrite morphogenesis [IMP]
- negative regulation of protein binding [ISO]
- negative regulation of protein kinase activity [ISO]
- negative regulation of protein phosphorylation [IGI]
- neuromuscular junction development [IGI]
- neurotransmitter secretion [IGI]
- planar cell polarity pathway involved in neural tube closure [IGI]
- positive regulation of Wnt signaling pathway [ISO]
- positive regulation of canonical Wnt signaling pathway [IMP]
- positive regulation of neuron projection development [IMP]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [ISO]
- positive regulation of protein phosphorylation [IDA]
- positive regulation of transcription, DNA-templated [ISO]
- prepulse inhibition [IMP]
- protein localization to microtubule [IGI]
- protein localization to nucleus [ISO]
- receptor clustering [IGI]
- regulation of neurotransmitter levels [IMP]
- regulation of protein phosphorylation [IGI]
- skeletal muscle acetylcholine-gated channel clustering [IMP]
- social behavior [IMP]
- synapse organization [IGI, IMP]
- transcription from RNA polymerase II promoter [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.
There are hundreds of risk genes associated with autism spectrum disorder (ASD), but signaling networks at the protein level remain unexplored. We use neuron-specific proximity-labeling proteomics (BioID2) to identify protein-protein interaction (PPI) networks for 41 ASD risk genes. Neuron-specific PPI networks, including synaptic transmission proteins, are disrupted by de novo missense variants. The PPI network map reveals convergent pathways, including ... [more]
Cell Rep Nov. 22, 2022; 41(8);111678 [Pubmed: 36417873]
Quantitative Score
- 0.137715856 [Relative Biotinylation Score]
Throughput
- High Throughput
Additional Notes
- BioID experiment
- The scores are relative biotinylation enrichment scores (calculated as a percentage of the abundance fold change of the highest biotinylated prey protein)
- The statistical cut-offs for the prey proteins are based on adjusted t-test p-value and significance B scores of less than 0.05, by comparing average abundances of prey proteins between the Bait-BioID samples and the luciferase-BioID control
Curated By
- BioGRID