BAIT
PPP5C
AU020526, PP5
protein phosphatase 5, catalytic subunit
GO Process (12)
GO Function (8)
GO Component (10)
Gene Ontology Biological Process
- dephosphorylation [IMP]
- histone dephosphorylation [ISO]
- negative regulation of cell death [ISO]
- negative regulation of neuron death [ISO]
- negative regulation of protein phosphorylation [ISO]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- positive regulation of glucocorticoid receptor signaling pathway [ISO]
- protein dephosphorylation [ISO]
- protein heterooligomerization [ISO]
- protein oligomerization [ISO]
- response to morphine [IMP]
- signal transduction [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
GSK3A
2700086H06Rik
glycogen synthase kinase 3 alpha
GO Process (26)
GO Function (4)
GO Component (0)
Gene Ontology Biological Process
- cardiac left ventricle morphogenesis [IMP]
- cell migration [IGI]
- cellular response to insulin stimulus [ISO]
- cellular response to interleukin-3 [IDA]
- cellular response to lithium ion [IDA]
- cellular response to organic cyclic compound [IDA]
- extrinsic apoptotic signaling pathway in absence of ligand [IDA]
- hypermethylation of CpG island [IMP]
- insulin receptor signaling pathway [IDA]
- negative regulation of TOR signaling [IMP]
- negative regulation of cell growth involved in cardiac muscle cell development [IMP]
- negative regulation of glucose import [ISO]
- negative regulation of insulin receptor signaling pathway [ISO]
- negative regulation of transferase activity [ISO]
- positive regulation of adrenergic receptor signaling pathway [IMP]
- positive regulation of cAMP biosynthetic process [IMP]
- positive regulation of glycogen (starch) synthase activity [IMP]
- positive regulation of heart contraction [IMP]
- positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [IDA]
- positive regulation of peptidyl-serine phosphorylation [IDA]
- positive regulation of peptidyl-threonine phosphorylation [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IDA]
- protein phosphorylation [IDA, IMP, ISO]
- regulation of gene expression by genetic imprinting [IMP]
- regulation of systemic arterial blood pressure [IMP]
Gene Ontology Molecular Function
Mus musculus
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.
There are hundreds of risk genes associated with autism spectrum disorder (ASD), but signaling networks at the protein level remain unexplored. We use neuron-specific proximity-labeling proteomics (BioID2) to identify protein-protein interaction (PPI) networks for 41 ASD risk genes. Neuron-specific PPI networks, including synaptic transmission proteins, are disrupted by de novo missense variants. The PPI network map reveals convergent pathways, including ... [more]
Cell Rep Nov. 22, 2022; 41(8);111678 [Pubmed: 36417873]
Quantitative Score
- 0.244766455 [Relative Biotinylation Score]
Throughput
- High Throughput
Additional Notes
- BioID experiment
- The scores are relative biotinylation enrichment scores (calculated as a percentage of the abundance fold change of the highest biotinylated prey protein)
- The statistical cut-offs for the prey proteins are based on adjusted t-test p-value and significance B scores of less than 0.05, by comparing average abundances of prey proteins between the Bait-BioID samples and the luciferase-BioID control
Curated By
- BioGRID