BAIT
PPP5C
AU020526, PP5
protein phosphatase 5, catalytic subunit
GO Process (12)
GO Function (8)
GO Component (10)
Gene Ontology Biological Process
- dephosphorylation [IMP]
- histone dephosphorylation [ISO]
- negative regulation of cell death [ISO]
- negative regulation of neuron death [ISO]
- negative regulation of protein phosphorylation [ISO]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- positive regulation of glucocorticoid receptor signaling pathway [ISO]
- protein dephosphorylation [ISO]
- protein heterooligomerization [ISO]
- protein oligomerization [ISO]
- response to morphine [IMP]
- signal transduction [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
NOS1
2310005C01Rik, NO, NOS-I, Nos-1, bNOS, nNOS
nitric oxide synthase 1, neuronal
GO Process (40)
GO Function (15)
GO Component (20)
Gene Ontology Biological Process
- arginine catabolic process [ISO]
- behavioral response to cocaine [ISO]
- cellular response to epinephrine stimulus [ISO]
- cellular response to growth factor stimulus [IMP]
- cellular response to mechanical stimulus [ISO]
- exogenous drug catabolic process [IMP]
- multicellular organismal response to stress [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of blood pressure [IBA, ISO]
- negative regulation of calcium ion transport [IMP]
- negative regulation of cell proliferation [ISO]
- negative regulation of cytosolic calcium ion concentration [ISO]
- negative regulation of heart contraction [ISO]
- negative regulation of hydrolase activity [IMP]
- negative regulation of insulin secretion [ISO]
- negative regulation of peptidyl-serine phosphorylation [ISO]
- negative regulation of potassium ion transport [IMP]
- negative regulation of serotonin uptake [IDA]
- negative regulation of vasoconstriction [ISO]
- nitric oxide biosynthetic process [IDA, ISO]
- nitric oxide mediated signal transduction [IBA, ISO]
- oxidation-reduction process [IBA]
- peptidyl-cysteine S-nitrosylation [IDA, ISO]
- positive regulation of adrenergic receptor signaling pathway involved in heart process [IMP]
- positive regulation of guanylate cyclase activity [IBA]
- positive regulation of histone acetylation [IMP]
- positive regulation of long-term synaptic potentiation [ISO]
- positive regulation of neuron death [ISO]
- positive regulation of sodium ion transmembrane transport [ISO]
- positive regulation of the force of heart contraction [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of transcription, DNA-templated [IMP]
- positive regulation of vasodilation [IBA, ISO]
- regulation of heart contraction [ISO]
- regulation of sensory perception of pain [ISO]
- regulation of sodium ion transport [IMP]
- response to estrogen [ISO]
- response to heat [ISO]
- response to peptide hormone [ISO]
- striated muscle contraction [IMP]
Gene Ontology Molecular Function- ATPase binding [ISO]
- FMN binding [ISO]
- NADP binding [ISO]
- NADPH-hemoprotein reductase activity [IBA]
- cadmium ion binding [ISO]
- calmodulin binding [ISO]
- enzyme binding [ISO]
- flavin adenine dinucleotide binding [ISO]
- heme binding [ISO]
- ion channel binding [ISO]
- nitric-oxide synthase activity [IDA, ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- scaffold protein binding [ISO]
- sodium channel regulator activity [ISO]
- ATPase binding [ISO]
- FMN binding [ISO]
- NADP binding [ISO]
- NADPH-hemoprotein reductase activity [IBA]
- cadmium ion binding [ISO]
- calmodulin binding [ISO]
- enzyme binding [ISO]
- flavin adenine dinucleotide binding [ISO]
- heme binding [ISO]
- ion channel binding [ISO]
- nitric-oxide synthase activity [IDA, ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- scaffold protein binding [ISO]
- sodium channel regulator activity [ISO]
Gene Ontology Cellular Component
- azurophil granule [ISO]
- cytoplasm [ISO]
- cytoskeleton [IDA]
- cytosol [IBA, ISO]
- dendrite [ISO]
- membrane [ISO]
- membrane raft [IDA]
- mitochondrial outer membrane [ISO]
- mitochondrion [ISO]
- nuclear membrane [ISO]
- nucleus [ISO]
- perinuclear region of cytoplasm [ISO]
- photoreceptor inner segment [ISO]
- plasma membrane [ISO]
- postsynaptic density [ISO]
- protein complex [ISO]
- sarcolemma [IDA, ISO]
- sarcoplasmic reticulum [ISO]
- synapse [IDA, ISO]
- vesicle membrane [ISO]
Mus musculus
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.
There are hundreds of risk genes associated with autism spectrum disorder (ASD), but signaling networks at the protein level remain unexplored. We use neuron-specific proximity-labeling proteomics (BioID2) to identify protein-protein interaction (PPI) networks for 41 ASD risk genes. Neuron-specific PPI networks, including synaptic transmission proteins, are disrupted by de novo missense variants. The PPI network map reveals convergent pathways, including ... [more]
Cell Rep Nov. 22, 2022; 41(8);111678 [Pubmed: 36417873]
Quantitative Score
- 0.231708334 [Relative Biotinylation Score]
Throughput
- High Throughput
Additional Notes
- BioID experiment
- The scores are relative biotinylation enrichment scores (calculated as a percentage of the abundance fold change of the highest biotinylated prey protein)
- The statistical cut-offs for the prey proteins are based on adjusted t-test p-value and significance B scores of less than 0.05, by comparing average abundances of prey proteins between the Bait-BioID samples and the luciferase-BioID control
Curated By
- BioGRID