BAIT
PPP5C
AU020526, PP5
protein phosphatase 5, catalytic subunit
GO Process (12)
GO Function (8)
GO Component (10)
Gene Ontology Biological Process
- dephosphorylation [IMP]
- histone dephosphorylation [ISO]
- negative regulation of cell death [ISO]
- negative regulation of neuron death [ISO]
- negative regulation of protein phosphorylation [ISO]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- positive regulation of glucocorticoid receptor signaling pathway [ISO]
- protein dephosphorylation [ISO]
- protein heterooligomerization [ISO]
- protein oligomerization [ISO]
- response to morphine [IMP]
- signal transduction [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
PER1
Per, m-rigui, mPer1, RP23-26L6.6
period circadian clock 1
GO Process (20)
GO Function (9)
GO Component (2)
Gene Ontology Biological Process
- circadian regulation of gene expression [IDA, IMP, ISO]
- circadian regulation of translation [IMP]
- circadian rhythm [ISO, TAS]
- entrainment of circadian clock by photoperiod [IMP]
- histone H3 acetylation [IDA, ISO]
- histone H3 deacetylation [IMP]
- histone H4 acetylation [ISO]
- negative regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- negative regulation of JNK cascade [ISO]
- negative regulation of glucocorticoid receptor signaling pathway [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- negative regulation of transcription, DNA-templated [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- posttranscriptional regulation of gene expression [IMP]
- regulation of circadian rhythm [IMP]
- regulation of cytokine production involved in inflammatory response [ISO]
- regulation of hair cycle [ISO]
- regulation of p38MAPK cascade [ISO]
- regulation of sodium ion transport [IMP]
- response to cAMP [IDA]
Gene Ontology Molecular Function- E-box binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- chromatin DNA binding [IDA]
- kinase binding [IPI, ISO]
- protein binding [IPI]
- transcription factor binding [IPI]
- transcription factor binding transcription factor activity [IDA]
- transcription regulatory region sequence-specific DNA binding [IDA]
- ubiquitin protein ligase binding [ISO]
- E-box binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- chromatin DNA binding [IDA]
- kinase binding [IPI, ISO]
- protein binding [IPI]
- transcription factor binding [IPI]
- transcription factor binding transcription factor activity [IDA]
- transcription regulatory region sequence-specific DNA binding [IDA]
- ubiquitin protein ligase binding [ISO]
Mus musculus
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.
There are hundreds of risk genes associated with autism spectrum disorder (ASD), but signaling networks at the protein level remain unexplored. We use neuron-specific proximity-labeling proteomics (BioID2) to identify protein-protein interaction (PPI) networks for 41 ASD risk genes. Neuron-specific PPI networks, including synaptic transmission proteins, are disrupted by de novo missense variants. The PPI network map reveals convergent pathways, including ... [more]
Cell Rep Nov. 22, 2022; 41(8);111678 [Pubmed: 36417873]
Quantitative Score
- 0.349425541 [Relative Biotinylation Score]
Throughput
- High Throughput
Additional Notes
- BioID experiment
- The scores are relative biotinylation enrichment scores (calculated as a percentage of the abundance fold change of the highest biotinylated prey protein)
- The statistical cut-offs for the prey proteins are based on adjusted t-test p-value and significance B scores of less than 0.05, by comparing average abundances of prey proteins between the Bait-BioID samples and the luciferase-BioID control
Curated By
- BioGRID