BAIT
PRKAR1B
AI385716, RIbeta
protein kinase, cAMP dependent regulatory, type I beta
GO Process (6)
GO Function (4)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
CACNA1B
AW050276, AW060892, AW822256, Cav2.2, Cchn1a, alpha(1B), RP23-264D16.5
calcium channel, voltage-dependent, N type, alpha 1B subunit
GO Process (15)
GO Function (5)
GO Component (10)
Gene Ontology Biological Process
- calcium ion import [IBA, ISO]
- calcium ion transmembrane transport [IBA, IMP]
- calcium ion transport [IMP, ISO]
- locomotory behavior [IMP]
- membrane depolarization during action potential [IBA]
- neurotransmitter secretion [IMP]
- positive regulation of neurotransmitter secretion [ISO]
- regulation of blood pressure [IMP]
- regulation of calcium ion transport [IMP]
- regulation of heart contraction [IMP]
- regulation of ion transmembrane transport [IMP]
- response to organic cyclic compound [ISO]
- response to pain [IMP]
- response to testosterone [ISO]
- sensory perception of pain [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.
There are hundreds of risk genes associated with autism spectrum disorder (ASD), but signaling networks at the protein level remain unexplored. We use neuron-specific proximity-labeling proteomics (BioID2) to identify protein-protein interaction (PPI) networks for 41 ASD risk genes. Neuron-specific PPI networks, including synaptic transmission proteins, are disrupted by de novo missense variants. The PPI network map reveals convergent pathways, including ... [more]
Cell Rep Nov. 22, 2022; 41(8);111678 [Pubmed: 36417873]
Quantitative Score
- 0.311927194 [Relative Biotinylation Score]
Throughput
- High Throughput
Additional Notes
- BioID experiment
- The scores are relative biotinylation enrichment scores (calculated as a percentage of the abundance fold change of the highest biotinylated prey protein)
- The statistical cut-offs for the prey proteins are based on adjusted t-test p-value and significance B scores of less than 0.05, by comparing average abundances of prey proteins between the Bait-BioID samples and the luciferase-BioID control
Curated By
- BioGRID