BAIT
PRKAR1B
AI385716, RIbeta
protein kinase, cAMP dependent regulatory, type I beta
GO Process (6)
GO Function (4)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
NCAM1
CD56, E-NCAM, NCAM-1, Ncam
neural cell adhesion molecule 1
GO Process (16)
GO Function (4)
GO Component (9)
Gene Ontology Biological Process
- aging [ISO]
- cell surface receptor signaling pathway [IDA]
- homotypic cell-cell adhesion [IMP]
- learning or memory [ISO]
- multicellular organismal response to stress [ISO]
- negative regulation of cell death [ISO]
- neuron development [ISO]
- neuron projection development [IGI]
- positive regulation of calcium-mediated signaling [IDA]
- positive regulation of cardiac muscle cell proliferation [ISO]
- regulation of exocyst assembly [IMP]
- regulation of sensory perception of pain [ISO]
- response to cocaine [ISO]
- response to fluoxetine [ISO]
- response to lead ion [ISO]
- thalamus development [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.
There are hundreds of risk genes associated with autism spectrum disorder (ASD), but signaling networks at the protein level remain unexplored. We use neuron-specific proximity-labeling proteomics (BioID2) to identify protein-protein interaction (PPI) networks for 41 ASD risk genes. Neuron-specific PPI networks, including synaptic transmission proteins, are disrupted by de novo missense variants. The PPI network map reveals convergent pathways, including ... [more]
Cell Rep Nov. 22, 2022; 41(8);111678 [Pubmed: 36417873]
Quantitative Score
- 0.424441737 [Relative Biotinylation Score]
Throughput
- High Throughput
Additional Notes
- BioID experiment
- The scores are relative biotinylation enrichment scores (calculated as a percentage of the abundance fold change of the highest biotinylated prey protein)
- The statistical cut-offs for the prey proteins are based on adjusted t-test p-value and significance B scores of less than 0.05, by comparing average abundances of prey proteins between the Bait-BioID samples and the luciferase-BioID control
Curated By
- BioGRID