BAIT
PRKAR1B
AI385716, RIbeta
protein kinase, cAMP dependent regulatory, type I beta
GO Process (6)
GO Function (4)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
POR
4933424M13Rik, CPR, CYPOR
P450 (cytochrome) oxidoreductase
GO Process (17)
GO Function (12)
GO Component (4)
Gene Ontology Biological Process
- cellular organofluorine metabolic process [ISO]
- demethylation [ISO]
- fatty acid oxidation [ISO]
- internal peptidyl-lysine acetylation [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- negative regulation of lipase activity [ISO]
- nitrate catabolic process [ISO]
- nitric oxide catabolic process [ISO]
- oxidation-reduction process [IMP, ISO]
- positive regulation of cholesterol biosynthetic process [ISO]
- positive regulation of chondrocyte differentiation [ISO]
- positive regulation of monooxygenase activity [ISO]
- positive regulation of smoothened signaling pathway [ISO]
- positive regulation of steroid hormone biosynthetic process [ISO]
- regulation of cholesterol metabolic process [ISO]
- regulation of growth plate cartilage chondrocyte proliferation [ISO]
Gene Ontology Molecular Function- FMN binding [ISO]
- NADP binding [ISO]
- NADPH-hemoprotein reductase activity [IBA, ISO]
- cytochrome-b5 reductase activity, acting on NAD(P)H [ISO]
- electron carrier activity [ISO]
- enzyme binding [ISO]
- flavin adenine dinucleotide binding [ISO]
- hydrolase activity [ISO]
- iron-cytochrome-c reductase activity [ISO]
- nitric oxide dioxygenase activity [ISO]
- oxidoreductase activity [IMP]
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [IBA]
- FMN binding [ISO]
- NADP binding [ISO]
- NADPH-hemoprotein reductase activity [IBA, ISO]
- cytochrome-b5 reductase activity, acting on NAD(P)H [ISO]
- electron carrier activity [ISO]
- enzyme binding [ISO]
- flavin adenine dinucleotide binding [ISO]
- hydrolase activity [ISO]
- iron-cytochrome-c reductase activity [ISO]
- nitric oxide dioxygenase activity [ISO]
- oxidoreductase activity [IMP]
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [IBA]
Gene Ontology Cellular Component
Mus musculus
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.
There are hundreds of risk genes associated with autism spectrum disorder (ASD), but signaling networks at the protein level remain unexplored. We use neuron-specific proximity-labeling proteomics (BioID2) to identify protein-protein interaction (PPI) networks for 41 ASD risk genes. Neuron-specific PPI networks, including synaptic transmission proteins, are disrupted by de novo missense variants. The PPI network map reveals convergent pathways, including ... [more]
Cell Rep Nov. 22, 2022; 41(8);111678 [Pubmed: 36417873]
Quantitative Score
- 0.340500253 [Relative Biotinylation Score]
Throughput
- High Throughput
Additional Notes
- BioID experiment
- The scores are relative biotinylation enrichment scores (calculated as a percentage of the abundance fold change of the highest biotinylated prey protein)
- The statistical cut-offs for the prey proteins are based on adjusted t-test p-value and significance B scores of less than 0.05, by comparing average abundances of prey proteins between the Bait-BioID samples and the luciferase-BioID control
Curated By
- BioGRID