BAIT
PRKAR1B
AI385716, RIbeta
protein kinase, cAMP dependent regulatory, type I beta
GO Process (6)
GO Function (4)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
SOD2
MnSOD, Sod-2
superoxide dismutase 2, mitochondrial
GO Process (51)
GO Function (6)
GO Component (7)
Gene Ontology Biological Process
- age-dependent response to oxidative stress [IMP]
- age-dependent response to reactive oxygen species [ISO]
- apoptotic mitochondrial changes [IMP]
- detection of oxygen [IMP]
- erythrophore differentiation [IMP]
- glutathione metabolic process [IMP]
- heart development [IMP]
- hemopoiesis [IMP]
- hydrogen peroxide biosynthetic process [ISO]
- hydrogen peroxide metabolic process [ISO]
- intrinsic apoptotic signaling pathway in response to DNA damage [IMP]
- intrinsic apoptotic signaling pathway in response to oxidative stress [IMP]
- iron ion homeostasis [IMP]
- liver development [IMP]
- locomotory behavior [IMP]
- mitochondrion organization [IMP]
- negative regulation of apoptotic process [ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of fat cell differentiation [IMP]
- negative regulation of fibroblast proliferation [IDA]
- negative regulation of neuron apoptotic process [ISO]
- negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [ISO]
- neuron development [IMP]
- oxidation-reduction process [ISO]
- oxygen homeostasis [ISO]
- positive regulation of nitric oxide biosynthetic process [IMP]
- post-embryonic development [IMP]
- protein homooligomerization [ISO]
- protein homotetramerization [ISO]
- regulation of blood pressure [IMP]
- regulation of catalytic activity [IMP]
- regulation of mitochondrial membrane potential [IMP]
- regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- release of cytochrome c from mitochondria [IMP]
- removal of superoxide radicals [IDA, IMP, ISO]
- respiratory electron transport chain [IMP]
- response to activity [IMP]
- response to axon injury [IMP]
- response to drug [ISO]
- response to gamma radiation [IGI]
- response to hydrogen peroxide [IMP]
- response to hyperoxia [IMP]
- response to nutrient levels [ISO]
- response to oxidative stress [IGI, IMP]
- response to reactive oxygen species [IMP]
- response to superoxide [IMP, ISO]
- sensory perception of sound [IMP]
- superoxide anion generation [IMP]
- superoxide metabolic process [IMP, ISO]
- vasodilation [IMP]
- vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.
There are hundreds of risk genes associated with autism spectrum disorder (ASD), but signaling networks at the protein level remain unexplored. We use neuron-specific proximity-labeling proteomics (BioID2) to identify protein-protein interaction (PPI) networks for 41 ASD risk genes. Neuron-specific PPI networks, including synaptic transmission proteins, are disrupted by de novo missense variants. The PPI network map reveals convergent pathways, including ... [more]
Cell Rep Nov. 22, 2022; 41(8);111678 [Pubmed: 36417873]
Quantitative Score
- 0.462910576 [Relative Biotinylation Score]
Throughput
- High Throughput
Additional Notes
- BioID experiment
- The scores are relative biotinylation enrichment scores (calculated as a percentage of the abundance fold change of the highest biotinylated prey protein)
- The statistical cut-offs for the prey proteins are based on adjusted t-test p-value and significance B scores of less than 0.05, by comparing average abundances of prey proteins between the Bait-BioID samples and the luciferase-BioID control
Curated By
- BioGRID