BAIT
PRKAR1B
AI385716, RIbeta
protein kinase, cAMP dependent regulatory, type I beta
GO Process (6)
GO Function (4)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
YBX1
1700102N10Rik, C79409, EF1A, MSY1, Nsep1, YB-1, dbpB, mYB-1a, RP24-363D14.2
Y box protein 1
GO Process (10)
GO Function (12)
GO Component (12)
Gene Ontology Biological Process
- CRD-mediated mRNA stabilization [ISO]
- in utero embryonic development [IGI, IMP]
- negative regulation of apoptotic process [ISO]
- negative regulation of insulin receptor signaling pathway [ISO]
- negative regulation of striated muscle cell differentiation [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IGI, ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- regulation of transcription, DNA-templated [ISO]
- transcription from RNA polymerase II promoter [ISO]
Gene Ontology Molecular Function- DNA binding [ISO]
- RNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- chromatin binding [IDA]
- mRNA binding [ISO]
- p53 binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- sequence-specific DNA binding [ISO]
- single-stranded DNA binding [IDA, ISO]
- transcription factor binding [ISO]
- DNA binding [ISO]
- RNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- chromatin binding [IDA]
- mRNA binding [ISO]
- p53 binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- sequence-specific DNA binding [ISO]
- single-stranded DNA binding [IDA, ISO]
- transcription factor binding [ISO]
Gene Ontology Cellular Component
- CRD-mediated mRNA stability complex [ISO]
- U12-type spliceosomal complex [ISO]
- cytoplasm [IDA, ISO]
- cytoplasmic stress granule [ISO]
- dendrite [ISO]
- extracellular vesicular exosome [ISO]
- histone pre-mRNA 3'end processing complex [IDA]
- intracellular membrane-bounded organelle [ISO]
- nuclear membrane [ISO]
- nucleus [IGI, ISO]
- perinuclear region of cytoplasm [ISO]
- ribonucleoprotein complex [ISO]
Mus musculus
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.
There are hundreds of risk genes associated with autism spectrum disorder (ASD), but signaling networks at the protein level remain unexplored. We use neuron-specific proximity-labeling proteomics (BioID2) to identify protein-protein interaction (PPI) networks for 41 ASD risk genes. Neuron-specific PPI networks, including synaptic transmission proteins, are disrupted by de novo missense variants. The PPI network map reveals convergent pathways, including ... [more]
Cell Rep Nov. 22, 2022; 41(8);111678 [Pubmed: 36417873]
Quantitative Score
- 0.431151961 [Relative Biotinylation Score]
Throughput
- High Throughput
Additional Notes
- BioID experiment
- The scores are relative biotinylation enrichment scores (calculated as a percentage of the abundance fold change of the highest biotinylated prey protein)
- The statistical cut-offs for the prey proteins are based on adjusted t-test p-value and significance B scores of less than 0.05, by comparing average abundances of prey proteins between the Bait-BioID samples and the luciferase-BioID control
Curated By
- BioGRID