BAIT
PTK7
8430404F20Rik, chz, mPTK7/CCK4
PTK7 protein tyrosine kinase 7
GO Process (15)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
- actin cytoskeleton reorganization [ISO]
- axis elongation [IMP]
- canonical Wnt signaling pathway [IBA, ISO]
- cell migration [ISO]
- cellular response to retinoic acid [ISO]
- cochlea morphogenesis [IMP]
- convergent extension [IMP]
- establishment of epithelial cell apical/basal polarity [IMP]
- establishment of planar polarity [IMP]
- lung-associated mesenchyme development [IMP]
- neural tube closure [IGI, IMP]
- planar cell polarity pathway involved in neural tube closure [IGI]
- positive regulation of neuron projection development [ISO]
- protein phosphorylation [IDA]
- wound healing [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
GABBR1
GABAB1, GABAbR1, bM573K1.1
gamma-aminobutyric acid (GABA) B receptor, 1
GO Process (13)
GO Function (3)
GO Component (18)
Gene Ontology Biological Process
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway [ISO]
- gamma-aminobutyric acid signaling pathway [IDA, ISO]
- negative regulation of adenylate cyclase activity [ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of dopamine secretion [ISO]
- negative regulation of epinephrine secretion [ISO]
- negative regulation of gamma-aminobutyric acid secretion [ISO]
- negative regulation of synaptic transmission [ISO]
- osteoblast differentiation [ISO]
- positive regulation of glutamate secretion [ISO]
- positive regulation of growth hormone secretion [ISO]
- regulation of cAMP biosynthetic process [ISO]
- regulation of glutamate secretion [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- G-protein coupled receptor dimeric complex [IDA]
- G-protein coupled receptor heterodimeric complex [ISO]
- axolemma [ISO]
- cytoplasm [IDA]
- dendritic shaft [ISO]
- dendritic spine [ISO]
- endoplasmic reticulum membrane [ISO]
- extracellular space [ISO]
- integral component of plasma membrane [ISO]
- intracellular membrane-bounded organelle [ISO]
- membrane [IDA]
- membrane raft [ISO]
- mitochondrial membrane [ISO]
- neuron projection [ISO]
- neuronal cell body [ISO]
- postsynaptic membrane [IDA]
- presynaptic membrane [IDA]
- synaptic vesicle [ISO]
Mus musculus
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.
There are hundreds of risk genes associated with autism spectrum disorder (ASD), but signaling networks at the protein level remain unexplored. We use neuron-specific proximity-labeling proteomics (BioID2) to identify protein-protein interaction (PPI) networks for 41 ASD risk genes. Neuron-specific PPI networks, including synaptic transmission proteins, are disrupted by de novo missense variants. The PPI network map reveals convergent pathways, including ... [more]
Cell Rep Nov. 22, 2022; 41(8);111678 [Pubmed: 36417873]
Quantitative Score
- 0.247411487 [Relative Biotinylation Score]
Throughput
- High Throughput
Additional Notes
- BioID experiment
- The scores are relative biotinylation enrichment scores (calculated as a percentage of the abundance fold change of the highest biotinylated prey protein)
- The statistical cut-offs for the prey proteins are based on adjusted t-test p-value and significance B scores of less than 0.05, by comparing average abundances of prey proteins between the Bait-BioID samples and the luciferase-BioID control
Curated By
- BioGRID