BAIT
RHEB
Rheb1
Ras homolog enriched in brain
GO Process (3)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
PRDX2
AL022839, Band-8, NkefB, PRP, PrxII, TDX1, TPx, TPx-B, TR, TSA, Tdpx1, Torin
peroxiredoxin 2
GO Process (22)
GO Function (5)
GO Component (4)
Gene Ontology Biological Process
- T cell proliferation [IMP]
- activation of MAPK activity [IMP]
- cellular response to oxidative stress [ISO]
- homeostasis of number of cells [IMP]
- hydrogen peroxide catabolic process [IMP]
- hydrogen peroxide metabolic process [IMP]
- negative regulation of NF-kappaB transcription factor activity [IMP]
- negative regulation of T cell differentiation [IMP]
- negative regulation of extrinsic apoptotic signaling pathway [IMP]
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [IDA]
- negative regulation of lipopolysaccharide-mediated signaling pathway [IMP]
- negative regulation of neuron apoptotic process [ISO]
- negative regulation of reactive oxygen species metabolic process [IMP]
- oxidation-reduction process [ISS]
- positive regulation of blood coagulation [IMP]
- regulation of apoptotic process [ISO]
- regulation of hydrogen peroxide metabolic process [IMP]
- removal of superoxide radicals [IMP, ISO]
- respiratory burst involved in inflammatory response [IMP]
- response to lipopolysaccharide [IMP]
- response to oxidative stress [ISO, TAS]
- thymus development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.
There are hundreds of risk genes associated with autism spectrum disorder (ASD), but signaling networks at the protein level remain unexplored. We use neuron-specific proximity-labeling proteomics (BioID2) to identify protein-protein interaction (PPI) networks for 41 ASD risk genes. Neuron-specific PPI networks, including synaptic transmission proteins, are disrupted by de novo missense variants. The PPI network map reveals convergent pathways, including ... [more]
Cell Rep Nov. 22, 2022; 41(8);111678 [Pubmed: 36417873]
Quantitative Score
- 0.179108788 [Relative Biotinylation Score]
Throughput
- High Throughput
Additional Notes
- BioID experiment
- The scores are relative biotinylation enrichment scores (calculated as a percentage of the abundance fold change of the highest biotinylated prey protein)
- The statistical cut-offs for the prey proteins are based on adjusted t-test p-value and significance B scores of less than 0.05, by comparing average abundances of prey proteins between the Bait-BioID samples and the luciferase-BioID control
Curated By
- BioGRID