BAIT
SLC6A1
A730043E01, GABATHG, GABATR, GAT-1, Gabt, Gabt1, Gat1, XT-1, Xtrp1
solute carrier family 6 (neurotransmitter transporter, GABA), member 1
GO Process (10)
GO Function (1)
GO Component (4)
Gene Ontology Biological Process
- amino acid transmembrane transport [ISO]
- gamma-aminobutyric acid import [ISO]
- learning [ISO]
- negative regulation of synaptic transmission, GABAergic [ISO]
- positive regulation of gamma-aminobutyric acid secretion [ISO]
- protein homooligomerization [ISO]
- response to organic substance [ISO]
- response to purine-containing compound [ISO]
- response to toxic substance [ISO]
- sodium ion transmembrane transport [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
MYO5A
9630007J19Rik, AI413174, AI661011, Dbv, MVa, Myo5, MyoVA, Sev-1, d, d-120J, flail, flr, RP24-189I2.1
myosin VA
GO Process (29)
GO Function (15)
GO Component (29)
Gene Ontology Biological Process
- actin filament-based movement [IDA, ISO]
- anagen [IMP]
- cellular response to insulin stimulus [IMP]
- developmental pigmentation [IMP]
- endoplasmic reticulum localization [IMP]
- exocytosis [IMP]
- insulin secretion [IMP]
- locomotion involved in locomotory behavior [IMP]
- long-chain fatty acid biosynthetic process [IMP]
- melanin biosynthetic process [IMP]
- melanin metabolic process [IMP]
- melanocyte differentiation [IMP]
- melanosome localization [IMP]
- melanosome transport [IDA, IMP]
- metabolic process [ISO]
- myelination [IMP]
- neuromuscular process controlling balance [IMP]
- odontogenesis [IDA]
- pigmentation [IMP, ISA]
- post-Golgi vesicle-mediated transport [ISO]
- protein localization to plasma membrane [IMP]
- regulation of exocytosis [ISO]
- regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [IMP]
- secretory granule localization [IMP, ISO]
- synapse organization [IMP]
- synaptic transmission [IMP]
- vesicle transport along actin filament [ISO, TAS]
- vesicle-mediated transport [IMP]
- visual perception [IMP]
Gene Ontology Molecular Function- ATP binding [ISO]
- ATP-dependent protein binding [ISO]
- Rab GTPase binding [IPI, ISO]
- SNARE binding [ISO]
- actin binding [IDA]
- calcium ion binding [IDA]
- calcium-dependent protein binding [ISO]
- calmodulin binding [IDA]
- microfilament motor activity [IDA, ISO]
- motor activity [IDA, ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein dimerization activity [ISO]
- protein heterodimerization activity [ISO]
- syntaxin-1 binding [ISO]
- ATP binding [ISO]
- ATP-dependent protein binding [ISO]
- Rab GTPase binding [IPI, ISO]
- SNARE binding [ISO]
- actin binding [IDA]
- calcium ion binding [IDA]
- calcium-dependent protein binding [ISO]
- calmodulin binding [IDA]
- microfilament motor activity [IDA, ISO]
- motor activity [IDA, ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein dimerization activity [ISO]
- protein heterodimerization activity [ISO]
- syntaxin-1 binding [ISO]
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- actin filament [ISO]
- actomyosin [IDA]
- actomyosin, myosin complex part [ISO]
- axon [ISO]
- cell [IMP]
- cytoplasm [IDA, ISO]
- cytosol [ISO]
- early endosome [ISO]
- endoplasmic reticulum [ISO]
- extracellular vesicular exosome [ISO]
- filopodium tip [ISO]
- insulin-responsive compartment [IDA]
- intermediate filament [IDA]
- late endosome [ISO]
- lysosome [ISO]
- melanosome [IDA]
- membrane [ISO]
- microtubule plus-end [IDA]
- myosin complex [IDA]
- neuron projection [ISO]
- neuronal cell body [IDA, ISO]
- peroxisome [ISO]
- photoreceptor outer segment [IDA]
- recycling endosome [ISO]
- ruffle [ISO]
- secretory granule [IDA, ISO]
- synaptic vesicle [ISO]
- vesicle [ISO]
Mus musculus
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.
There are hundreds of risk genes associated with autism spectrum disorder (ASD), but signaling networks at the protein level remain unexplored. We use neuron-specific proximity-labeling proteomics (BioID2) to identify protein-protein interaction (PPI) networks for 41 ASD risk genes. Neuron-specific PPI networks, including synaptic transmission proteins, are disrupted by de novo missense variants. The PPI network map reveals convergent pathways, including ... [more]
Cell Rep Nov. 22, 2022; 41(8);111678 [Pubmed: 36417873]
Quantitative Score
- 0.283567756 [Relative Biotinylation Score]
Throughput
- High Throughput
Additional Notes
- BioID experiment
- The scores are relative biotinylation enrichment scores (calculated as a percentage of the abundance fold change of the highest biotinylated prey protein)
- The statistical cut-offs for the prey proteins are based on adjusted t-test p-value and significance B scores of less than 0.05, by comparing average abundances of prey proteins between the Bait-BioID samples and the luciferase-BioID control
Curated By
- BioGRID