BAIT
SLC6A1
A730043E01, GABATHG, GABATR, GAT-1, Gabt, Gabt1, Gat1, XT-1, Xtrp1
solute carrier family 6 (neurotransmitter transporter, GABA), member 1
GO Process (10)
GO Function (1)
GO Component (4)
Gene Ontology Biological Process
- amino acid transmembrane transport [ISO]
- gamma-aminobutyric acid import [ISO]
- learning [ISO]
- negative regulation of synaptic transmission, GABAergic [ISO]
- positive regulation of gamma-aminobutyric acid secretion [ISO]
- protein homooligomerization [ISO]
- response to organic substance [ISO]
- response to purine-containing compound [ISO]
- response to toxic substance [ISO]
- sodium ion transmembrane transport [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
SERPINE2
B230326M24Rik, PAI-1, PI-7, PI7, PN-1, Spi4
serine (or cysteine) peptidase inhibitor, clade E, member 2
GO Process (29)
GO Function (4)
GO Component (11)
Gene Ontology Biological Process
- blood coagulation [IMP]
- cerebellar granular layer morphogenesis [IMP]
- dense core granule biogenesis [ISO]
- detection of mechanical stimulus involved in sensory perception [IMP]
- innervation [IMP]
- long-term synaptic potentiation [IMP]
- mating plug formation [IMP]
- negative regulation of blood coagulation [ISO]
- negative regulation of cell growth [IGI]
- negative regulation of cell proliferation [IGI]
- negative regulation of endopeptidase activity [IMP]
- negative regulation of peptidase activity [IMP]
- negative regulation of phosphatidylinositol 3-kinase signaling [IGI]
- negative regulation of plasminogen activation [IMP, ISO]
- negative regulation of platelet activation [IMP]
- negative regulation of platelet aggregation [IMP]
- negative regulation of protein catabolic process [IMP, ISO]
- negative regulation of protein processing [IC]
- negative regulation of proteolysis [ISO]
- negative regulation of smoothened signaling pathway [IGI]
- negative regulation of sodium ion transport [IGI, IMP]
- positive regulation of astrocyte differentiation [ISO]
- positive regulation of neuron projection development [ISO]
- regulation of synaptic transmission, glutamatergic [IMP]
- regulation of timing of cell differentiation [IMP]
- response to wounding [IMP]
- secretion by cell [IMP, ISO]
- secretory granule organization [IMP, ISO]
- seminal vesicle epithelium development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.
There are hundreds of risk genes associated with autism spectrum disorder (ASD), but signaling networks at the protein level remain unexplored. We use neuron-specific proximity-labeling proteomics (BioID2) to identify protein-protein interaction (PPI) networks for 41 ASD risk genes. Neuron-specific PPI networks, including synaptic transmission proteins, are disrupted by de novo missense variants. The PPI network map reveals convergent pathways, including ... [more]
Cell Rep Nov. 22, 2022; 41(8);111678 [Pubmed: 36417873]
Quantitative Score
- 0.296093872 [Relative Biotinylation Score]
Throughput
- High Throughput
Additional Notes
- BioID experiment
- The scores are relative biotinylation enrichment scores (calculated as a percentage of the abundance fold change of the highest biotinylated prey protein)
- The statistical cut-offs for the prey proteins are based on adjusted t-test p-value and significance B scores of less than 0.05, by comparing average abundances of prey proteins between the Bait-BioID samples and the luciferase-BioID control
Curated By
- BioGRID