BAIT
STXBP1
AI317162, AI326233, MMS10-G, Ms10g, Munc-18a, Munc18-1, N-sec1, Rb-sec1, Sxtbp1, Unc18-1, Unc18h, nsec1, RP23-17P12.13-002
syntaxin binding protein 1
GO Process (16)
GO Function (9)
GO Component (10)
Gene Ontology Biological Process
- axon target recognition [IMP]
- exocytosis [IMP]
- long term synaptic depression [IMP]
- negative regulation of neuron apoptotic process [IMP]
- negative regulation of synaptic transmission, GABAergic [IDA]
- neuromuscular synaptic transmission [IMP]
- neurotransmitter secretion [IMP]
- platelet aggregation [ISO]
- platelet degranulation [ISO]
- positive regulation of calcium ion-dependent exocytosis [IDA]
- positive regulation of exocytosis [ISO]
- protein localization to plasma membrane [ISO]
- protein stabilization [ISO]
- regulation of synaptic vesicle priming [ISO]
- synaptic vesicle maturation [IMP]
- vesicle docking involved in exocytosis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
CXADR
2610206D03Rik, AU016810, AW553441, CAR, MCAR, MCVADR
coxsackie virus and adenovirus receptor
GO Process (16)
GO Function (8)
GO Component (18)
Gene Ontology Biological Process
- AV node cell to bundle of His cell communication [IMP]
- actin cytoskeleton reorganization [ISO]
- cardiac muscle fiber development [IMP]
- cell-cell junction organization [IMP]
- defense response to virus [ISO]
- epithelial structure maintenance [ISO]
- gamma-delta T cell activation [IDA]
- heart development [IMP]
- heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [ISO]
- homotypic cell-cell adhesion [ISO]
- mitochondrion organization [IMP]
- negative regulation of cardiac muscle cell proliferation [IMP]
- neutrophil chemotaxis [ISO]
- positive regulation of epithelial cell proliferation involved in wound healing [IC]
- single organismal cell-cell adhesion [IMP]
- transepithelial transport [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- acrosomal vesicle [IDA]
- adherens junction [ISO]
- apicolateral plasma membrane [ISO]
- basolateral plasma membrane [IDA, ISO]
- cell body [IDA]
- cell junction [ISO]
- cell-cell junction [IDA, ISO]
- extracellular space [ISO]
- filopodium [IDA]
- growth cone [IDA]
- intercalated disc [IDA, ISO]
- membrane raft [ISO]
- neuromuscular junction [ISO]
- neuron projection [IDA, ISO]
- nucleoplasm [ISO]
- plasma membrane [ISO]
- protein complex [ISO]
- tight junction [IDA, ISO]
Mus musculus
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.
There are hundreds of risk genes associated with autism spectrum disorder (ASD), but signaling networks at the protein level remain unexplored. We use neuron-specific proximity-labeling proteomics (BioID2) to identify protein-protein interaction (PPI) networks for 41 ASD risk genes. Neuron-specific PPI networks, including synaptic transmission proteins, are disrupted by de novo missense variants. The PPI network map reveals convergent pathways, including ... [more]
Cell Rep Nov. 22, 2022; 41(8);111678 [Pubmed: 36417873]
Quantitative Score
- 0.536387135 [Relative Biotinylation Score]
Throughput
- High Throughput
Additional Notes
- BioID experiment
- The scores are relative biotinylation enrichment scores (calculated as a percentage of the abundance fold change of the highest biotinylated prey protein)
- The statistical cut-offs for the prey proteins are based on adjusted t-test p-value and significance B scores of less than 0.05, by comparing average abundances of prey proteins between the Bait-BioID samples and the luciferase-BioID control
Curated By
- BioGRID