BAIT
SYNGAP1
Gm1963, Syngap
synaptic Ras GTPase activating protein 1 homolog (rat)
GO Process (14)
GO Function (4)
GO Component (7)
Gene Ontology Biological Process
- Ras protein signal transduction [IDA]
- dendrite development [IMP]
- negative regulation of Ras protein signal transduction [IBA, ISO]
- negative regulation of axonogenesis [IDA]
- negative regulation of neuron apoptotic process [IMP]
- pattern specification process [IMP]
- positive regulation of Rab GTPase activity [IDA]
- positive regulation of Ras GTPase activity [IBA, ISO]
- receptor clustering [IMP]
- regulation of MAPK cascade [IMP]
- regulation of long-term neuronal synaptic plasticity [IGI, IMP]
- regulation of synapse structure or activity [IMP]
- regulation of synaptic plasticity [ISO]
- visual learning [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
ALDH5A1
6330403E24Rik, Ahd-1, Ahd1, D630032B01Rik, OTTMUSG00000000613, SSADH, Ssdh1, RP23-92G13.10-001
aldhehyde dehydrogenase family 5, subfamily A1
GO Process (18)
GO Function (5)
GO Component (1)
Gene Ontology Biological Process
- acetate metabolic process [IMP]
- central nervous system development [ISO]
- galactosylceramide metabolic process [IMP]
- gamma-aminobutyric acid catabolic process [IMP, ISO]
- gamma-aminobutyric acid metabolic process [IMP]
- glucose metabolic process [IMP]
- glucosylceramide metabolic process [IMP]
- glutamate metabolic process [IMP]
- glutamine metabolic process [IMP]
- glutathione metabolic process [IMP]
- glycerophospholipid metabolic process [IMP]
- neurotransmitter catabolic process [IMP]
- oxidation-reduction process [IBA, ISO]
- post-embryonic development [IMP]
- protein homotetramerization [ISO]
- respiratory electron transport chain [IMP]
- short-chain fatty acid metabolic process [IMP]
- succinate metabolic process [IMP, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- mitochondrion [IDA, ISO]
Mus musculus
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.
There are hundreds of risk genes associated with autism spectrum disorder (ASD), but signaling networks at the protein level remain unexplored. We use neuron-specific proximity-labeling proteomics (BioID2) to identify protein-protein interaction (PPI) networks for 41 ASD risk genes. Neuron-specific PPI networks, including synaptic transmission proteins, are disrupted by de novo missense variants. The PPI network map reveals convergent pathways, including ... [more]
Cell Rep Nov. 22, 2022; 41(8);111678 [Pubmed: 36417873]
Quantitative Score
- 0.38252187 [Relative Biotinylation Score]
Throughput
- High Throughput
Additional Notes
- BioID experiment
- The scores are relative biotinylation enrichment scores (calculated as a percentage of the abundance fold change of the highest biotinylated prey protein)
- The statistical cut-offs for the prey proteins are based on adjusted t-test p-value and significance B scores of less than 0.05, by comparing average abundances of prey proteins between the Bait-BioID samples and the luciferase-BioID control
Curated By
- BioGRID