SYNGAP1
Gene Ontology Biological Process
- Ras protein signal transduction [IDA]
- dendrite development [IMP]
- negative regulation of Ras protein signal transduction [IBA, ISO]
- negative regulation of axonogenesis [IDA]
- negative regulation of neuron apoptotic process [IMP]
- pattern specification process [IMP]
- positive regulation of Rab GTPase activity [IDA]
- positive regulation of Ras GTPase activity [IBA, ISO]
- receptor clustering [IMP]
- regulation of MAPK cascade [IMP]
- regulation of long-term neuronal synaptic plasticity [IGI, IMP]
- regulation of synapse structure or activity [IMP]
- regulation of synaptic plasticity [ISO]
- visual learning [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ANK2
Gene Ontology Biological Process
- SA node cell action potential [IMP]
- SA node cell to atrial cardiac muscle cell communication [IMP]
- T-tubule organization [IMP]
- atrial cardiac muscle cell action potential [IMP]
- atrial cardiac muscle cell to AV node cell communication [IMP]
- cardiac muscle contraction [IMP]
- cellular calcium ion homeostasis [IMP]
- cellular protein localization [IMP]
- positive regulation of calcium ion transmembrane transporter activity [IMP]
- positive regulation of calcium ion transport [IMP]
- positive regulation of cation channel activity [IMP]
- positive regulation of gene expression [IMP]
- positive regulation of potassium ion transmembrane transporter activity [IMP]
- positive regulation of potassium ion transport [IMP]
- protein localization [IMP]
- protein localization to M-band [IMP]
- protein localization to T-tubule [IMP]
- protein localization to cell surface [IMP]
- protein localization to endoplasmic reticulum [IMP]
- protein localization to plasma membrane [IMP]
- protein stabilization [IMP]
- protein targeting to plasma membrane [IGI, IMP]
- regulation of calcium ion transmembrane transporter activity [IMP]
- regulation of calcium ion transport [IMP]
- regulation of cardiac muscle cell contraction [IMP]
- regulation of cardiac muscle cell membrane potential [IGI, IMP]
- regulation of cardiac muscle contraction [IMP]
- regulation of cardiac muscle contraction by calcium ion signaling [IMP]
- regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [IC, IMP]
- regulation of cation channel activity [IMP]
- regulation of heart rate [IMP]
- regulation of heart rate by cardiac conduction [IMP]
- regulation of protein stability [IC]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- A band [IDA]
- M band [IDA, IMP]
- T-tubule [IDA]
- Z disc [IDA]
- cell [IGI]
- costamere [IDA]
- cytoplasm [IDA]
- integral component of plasma membrane [IDA]
- intercalated disc [IDA]
- intracellular [IGI, IMP]
- neuronal postsynaptic density [IDA]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [IDA, IMP]
- sarcolemma [IDA, IMP]
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.
There are hundreds of risk genes associated with autism spectrum disorder (ASD), but signaling networks at the protein level remain unexplored. We use neuron-specific proximity-labeling proteomics (BioID2) to identify protein-protein interaction (PPI) networks for 41 ASD risk genes. Neuron-specific PPI networks, including synaptic transmission proteins, are disrupted by de novo missense variants. The PPI network map reveals convergent pathways, including ... [more]
Quantitative Score
- 0.238790034 [Relative Biotinylation Score]
Throughput
- High Throughput
Additional Notes
- BioID experiment
- The scores are relative biotinylation enrichment scores (calculated as a percentage of the abundance fold change of the highest biotinylated prey protein)
- The statistical cut-offs for the prey proteins are based on adjusted t-test p-value and significance B scores of less than 0.05, by comparing average abundances of prey proteins between the Bait-BioID samples and the luciferase-BioID control
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
SYNGAP1 ANK2 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | - | |
SYNGAP1 ANK2 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | 2343608 | |
SYNGAP1 ANK2 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | 2333234 |
Curated By
- BioGRID