SYNGAP1
Gene Ontology Biological Process
- Ras protein signal transduction [IDA]
- dendrite development [IMP]
- negative regulation of Ras protein signal transduction [IBA, ISO]
- negative regulation of axonogenesis [IDA]
- negative regulation of neuron apoptotic process [IMP]
- pattern specification process [IMP]
- positive regulation of Rab GTPase activity [IDA]
- positive regulation of Ras GTPase activity [IBA, ISO]
- receptor clustering [IMP]
- regulation of MAPK cascade [IMP]
- regulation of long-term neuronal synaptic plasticity [IGI, IMP]
- regulation of synapse structure or activity [IMP]
- regulation of synaptic plasticity [ISO]
- visual learning [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
DLG3
Gene Ontology Biological Process
- embryo development [IBA]
- establishment of planar polarity [IMP]
- establishment or maintenance of epithelial cell apical/basal polarity [IMP]
- negative regulation of phosphatase activity [ISO]
- nervous system development [IBA]
- nucleotide phosphorylation [IBA]
- receptor clustering [IBA]
- receptor localization to synapse [IBA]
- synaptic transmission [IBA]
Gene Ontology Molecular Function- PDZ domain binding [ISO]
- guanylate kinase activity [IBA]
- ionotropic glutamate receptor binding [IBA, ISO]
- kinase binding [ISO]
- phosphatase binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- protein phosphatase binding [ISO]
- ubiquitin protein ligase binding [IPI]
- PDZ domain binding [ISO]
- guanylate kinase activity [IBA]
- ionotropic glutamate receptor binding [IBA, ISO]
- kinase binding [ISO]
- phosphatase binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- protein phosphatase binding [ISO]
- ubiquitin protein ligase binding [IPI]
Gene Ontology Cellular Component
- alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex [IDA]
- basolateral plasma membrane [IBA]
- cell-cell junction [IDA]
- cytoplasm [IDA]
- dendritic shaft [ISO]
- extracellular space [ISO]
- growth cone [ISO]
- neuronal cell body [ISO]
- plasma membrane [IDA]
- postsynaptic density [IBA, ISO]
- postsynaptic membrane [IBA]
- synapse [ISO]
- tight junction [IDA]
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.
There are hundreds of risk genes associated with autism spectrum disorder (ASD), but signaling networks at the protein level remain unexplored. We use neuron-specific proximity-labeling proteomics (BioID2) to identify protein-protein interaction (PPI) networks for 41 ASD risk genes. Neuron-specific PPI networks, including synaptic transmission proteins, are disrupted by de novo missense variants. The PPI network map reveals convergent pathways, including ... [more]
Quantitative Score
- 0.565479834 [Relative Biotinylation Score]
Throughput
- High Throughput
Additional Notes
- BioID experiment
- The scores are relative biotinylation enrichment scores (calculated as a percentage of the abundance fold change of the highest biotinylated prey protein)
- The statistical cut-offs for the prey proteins are based on adjusted t-test p-value and significance B scores of less than 0.05, by comparing average abundances of prey proteins between the Bait-BioID samples and the luciferase-BioID control
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
SYNGAP1 DLG3 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | - | |
SYNGAP1 DLG3 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | 2343628 | |
SYNGAP1 DLG3 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | 2333262 |
Curated By
- BioGRID