SYNGAP1
Gene Ontology Biological Process
- Ras protein signal transduction [IDA]
- dendrite development [IMP]
- negative regulation of Ras protein signal transduction [IBA, ISO]
- negative regulation of axonogenesis [IDA]
- negative regulation of neuron apoptotic process [IMP]
- pattern specification process [IMP]
- positive regulation of Rab GTPase activity [IDA]
- positive regulation of Ras GTPase activity [IBA, ISO]
- receptor clustering [IMP]
- regulation of MAPK cascade [IMP]
- regulation of long-term neuronal synaptic plasticity [IGI, IMP]
- regulation of synapse structure or activity [IMP]
- regulation of synaptic plasticity [ISO]
- visual learning [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SHANK3
Gene Ontology Biological Process
- MAPK cascade [IGI]
- N-methyl-D-aspartate receptor clustering [IMP]
- adult behavior [ISO]
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering [IMP]
- brain morphogenesis [IMP]
- dendritic spine morphogenesis [IMP]
- embryonic epithelial tube formation [IGI]
- guanylate kinase-associated protein clustering [IMP]
- learning [IMP, ISO]
- locomotory exploration behavior [IMP]
- memory [IMP]
- negative regulation of actin filament bundle assembly [IDA]
- negative regulation of cell volume [IMP]
- neuromuscular process controlling balance [IMP]
- positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [IMP]
- positive regulation of dendritic spine development [IMP]
- positive regulation of excitatory postsynaptic membrane potential [IMP]
- positive regulation of glutamate receptor signaling pathway [IMP, ISO]
- positive regulation of long-term neuronal synaptic plasticity [IMP]
- positive regulation of synapse structural plasticity [IMP]
- positive regulation of synaptic transmission, glutamatergic [IMP]
- postsynaptic density assembly [IMP]
- protein oligomerization [ISO]
- regulation of behavioral fear response [IMP]
- regulation of dendritic spine morphogenesis [IMP]
- regulation of grooming behavior [IMP]
- regulation of long term synaptic depression [IMP]
- regulation of long-term synaptic potentiation [IMP]
- social behavior [IMP, ISO]
- striatal medium spiny neuron differentiation [IMP]
- synapse assembly [IMP]
- vocal learning [ISO]
- vocalization behavior [IMP, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.
There are hundreds of risk genes associated with autism spectrum disorder (ASD), but signaling networks at the protein level remain unexplored. We use neuron-specific proximity-labeling proteomics (BioID2) to identify protein-protein interaction (PPI) networks for 41 ASD risk genes. Neuron-specific PPI networks, including synaptic transmission proteins, are disrupted by de novo missense variants. The PPI network map reveals convergent pathways, including ... [more]
Quantitative Score
- 0.477766548 [Relative Biotinylation Score]
Throughput
- High Throughput
Additional Notes
- BioID experiment
- The scores are relative biotinylation enrichment scores (calculated as a percentage of the abundance fold change of the highest biotinylated prey protein)
- The statistical cut-offs for the prey proteins are based on adjusted t-test p-value and significance B scores of less than 0.05, by comparing average abundances of prey proteins between the Bait-BioID samples and the luciferase-BioID control
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SYNGAP1 SHANK3 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | - | |
| SHANK3 SYNGAP1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | - | |
| SHANK3 SYNGAP1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | 2334091 | |
| SYNGAP1 SHANK3 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | 2343670 | |
| SYNGAP1 SHANK3 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | 2333333 |
Curated By
- BioGRID