BAIT
TAOK2
1110033K02Rik, B230344N16, MAP3K17, PSK, PSK1, TAO1, TAO2, mKIAA0881
TAO kinase 2
GO Process (13)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
- G2 DNA damage checkpoint [ISO]
- MAPK cascade [IBA]
- actin cytoskeleton organization [ISO]
- activation of MAPKK activity [IBA, ISO]
- cellular response to DNA damage stimulus [ISO]
- focal adhesion assembly [ISO]
- intracellular signal transduction [IBA]
- positive regulation of JNK cascade [ISO]
- positive regulation of stress-activated MAPK cascade [ISO]
- protein phosphorylation [IBA]
- regulation of cell shape [ISO]
- response to stress [IBA, ISO]
- stress-activated MAPK cascade [ISO]
Gene Ontology Molecular Function
Mus musculus
PREY
CS
2610511A05Rik, 9030605P22Rik, BB234005, Cis, ahl4
citrate synthase
GO Process (5)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.
There are hundreds of risk genes associated with autism spectrum disorder (ASD), but signaling networks at the protein level remain unexplored. We use neuron-specific proximity-labeling proteomics (BioID2) to identify protein-protein interaction (PPI) networks for 41 ASD risk genes. Neuron-specific PPI networks, including synaptic transmission proteins, are disrupted by de novo missense variants. The PPI network map reveals convergent pathways, including ... [more]
Cell Rep Nov. 22, 2022; 41(8);111678 [Pubmed: 36417873]
Quantitative Score
- 0.222165643 [Relative Biotinylation Score]
Throughput
- High Throughput
Additional Notes
- BioID experiment
- The scores are relative biotinylation enrichment scores (calculated as a percentage of the abundance fold change of the highest biotinylated prey protein)
- The statistical cut-offs for the prey proteins are based on adjusted t-test p-value and significance B scores of less than 0.05, by comparing average abundances of prey proteins between the Bait-BioID samples and the luciferase-BioID control
Curated By
- BioGRID