BAIT
TAOK2
1110033K02Rik, B230344N16, MAP3K17, PSK, PSK1, TAO1, TAO2, mKIAA0881
TAO kinase 2
GO Process (13)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
- G2 DNA damage checkpoint [ISO]
- MAPK cascade [IBA]
- actin cytoskeleton organization [ISO]
- activation of MAPKK activity [IBA, ISO]
- cellular response to DNA damage stimulus [ISO]
- focal adhesion assembly [ISO]
- intracellular signal transduction [IBA]
- positive regulation of JNK cascade [ISO]
- positive regulation of stress-activated MAPK cascade [ISO]
- protein phosphorylation [IBA]
- regulation of cell shape [ISO]
- response to stress [IBA, ISO]
- stress-activated MAPK cascade [ISO]
Gene Ontology Molecular Function
Mus musculus
PREY
DVL1
Dvl, mKIAA4029, RP23-242K15.15-003
dishevelled, dsh homolog 1 (Drosophila)
GO Process (34)
GO Function (6)
GO Component (14)
Gene Ontology Biological Process
- Wnt signaling pathway [IGI, NAS, TAS]
- Wnt signaling pathway, planar cell polarity pathway [IDA, IGI, IMP, ISO]
- axon extension [IDA]
- axon guidance [IDA]
- axonogenesis [IDA]
- canonical Wnt signaling pathway [IDA, IGI, IMP, ISO]
- cochlea morphogenesis [IGI]
- collateral sprouting [IDA]
- convergent extension involved in neural plate elongation [IGI]
- convergent extension involved in organogenesis [IGI, IMP]
- cytoplasmic microtubule organization [IDA, IGI]
- dendrite morphogenesis [IMP]
- negative regulation of protein binding [ISO]
- negative regulation of protein kinase activity [ISO]
- negative regulation of protein phosphorylation [IGI]
- neuromuscular junction development [IGI]
- neurotransmitter secretion [IGI]
- planar cell polarity pathway involved in neural tube closure [IGI]
- positive regulation of Wnt signaling pathway [ISO]
- positive regulation of canonical Wnt signaling pathway [IMP]
- positive regulation of neuron projection development [IMP]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [ISO]
- positive regulation of protein phosphorylation [IDA]
- positive regulation of transcription, DNA-templated [ISO]
- prepulse inhibition [IMP]
- protein localization to microtubule [IGI]
- protein localization to nucleus [ISO]
- receptor clustering [IGI]
- regulation of neurotransmitter levels [IMP]
- regulation of protein phosphorylation [IGI]
- skeletal muscle acetylcholine-gated channel clustering [IMP]
- social behavior [IMP]
- synapse organization [IGI, IMP]
- transcription from RNA polymerase II promoter [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.
There are hundreds of risk genes associated with autism spectrum disorder (ASD), but signaling networks at the protein level remain unexplored. We use neuron-specific proximity-labeling proteomics (BioID2) to identify protein-protein interaction (PPI) networks for 41 ASD risk genes. Neuron-specific PPI networks, including synaptic transmission proteins, are disrupted by de novo missense variants. The PPI network map reveals convergent pathways, including ... [more]
Cell Rep Nov. 22, 2022; 41(8);111678 [Pubmed: 36417873]
Quantitative Score
- 0.440989831 [Relative Biotinylation Score]
Throughput
- High Throughput
Additional Notes
- BioID experiment
- The scores are relative biotinylation enrichment scores (calculated as a percentage of the abundance fold change of the highest biotinylated prey protein)
- The statistical cut-offs for the prey proteins are based on adjusted t-test p-value and significance B scores of less than 0.05, by comparing average abundances of prey proteins between the Bait-BioID samples and the luciferase-BioID control
Curated By
- BioGRID