SLC38A7
Gene Ontology Biological Process
- L-alanine transport [IBA]
- L-aspartate transmembrane transport [IBA]
- L-glutamate transmembrane transport [IBA]
- L-glutamate transport [IBA]
- L-histidine transmembrane transport [IBA]
- L-serine transport [IBA]
- amino acid transmembrane transport [IBA]
- asparagine transport [IBA]
- aspartate transport [IBA]
- cation transmembrane transport [IBA]
- glutamine transport [IBA]
- histidine transport [IBA]
- methionine transport [IBA]
- sodium ion transport [ISS]
Gene Ontology Molecular Function- L-alanine transmembrane transporter activity [IBA]
- L-amino acid transmembrane transporter activity [ISS]
- L-asparagine transmembrane transporter activity [IBA]
- L-aspartate transmembrane transporter activity [IBA]
- L-glutamate transmembrane transporter activity [IBA]
- L-glutamine transmembrane transporter activity [IBA, ISS]
- L-histidine transmembrane transporter activity [IBA]
- L-leucine transmembrane transporter activity [IBA]
- L-methionine transmembrane transporter activity [IBA]
- L-serine transmembrane transporter activity [IBA]
- L-alanine transmembrane transporter activity [IBA]
- L-amino acid transmembrane transporter activity [ISS]
- L-asparagine transmembrane transporter activity [IBA]
- L-aspartate transmembrane transporter activity [IBA]
- L-glutamate transmembrane transporter activity [IBA]
- L-glutamine transmembrane transporter activity [IBA, ISS]
- L-histidine transmembrane transporter activity [IBA]
- L-leucine transmembrane transporter activity [IBA]
- L-methionine transmembrane transporter activity [IBA]
- L-serine transmembrane transporter activity [IBA]
Gene Ontology Cellular Component
LAMTOR1
Gene Ontology Biological Process
- cell growth [IMP]
- cellular protein localization [IMP]
- cellular response to amino acid stimulus [IMP]
- cholesterol homeostasis [IMP]
- endosome localization [ISS]
- endosome organization [ISS]
- lysosome localization [ISS]
- lysosome organization [ISS]
- positive regulation of GTPase activity [IDA]
- positive regulation of MAPK cascade [ISS]
- positive regulation of TOR signaling [IMP]
- regulation of cholesterol efflux [IMP]
- regulation of cholesterol esterification [IMP]
- regulation of cholesterol import [IMP]
- regulation of receptor recycling [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
SNAT7 regulates mTORC1 via macropinocytosis.
Mammalian target of rapamycin complex 1 (mTORC1) senses amino acids to control cell growth, metabolism, and autophagy. Some amino acids signal to mTORC1 through the Rag GTPase, whereas glutamine and asparagine activate mTORC1 through a Rag GTPase-independent pathway. Here, we show that the lysosomal glutamine and asparagine transporter SNAT7 activates mTORC1 after extracellular protein, such as albumin, is macropinocytosed. The ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID