BAIT
PLEKHM1
AP162, B2, OPTB6
pleckstrin homology domain containing, family M (with RUN domain) member 1
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY
STX7
RP11-560I21.1
syntaxin 7
GO Process (8)
GO Function (4)
GO Component (18)
Gene Ontology Biological Process
- intracellular protein transport [IBA]
- organelle assembly [IDA]
- organelle localization [IDA]
- positive regulation of T cell mediated cytotoxicity [IMP]
- positive regulation of receptor localization to synapse [IMP]
- regulation of protein localization to plasma membrane [IDA]
- vesicle docking [IBA]
- vesicle fusion [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- SNARE complex [IBA]
- azurophil granule [IDA]
- early endosome [IDA]
- endocytic vesicle [IDA]
- endomembrane system [IBA]
- endosome [IDA]
- extracellular vesicular exosome [IDA]
- immunological synapse [IDA]
- integral component of membrane [IBA]
- intracellular membrane-bounded organelle [IDA]
- late endosome [IDA]
- lysosomal membrane [IDA]
- lysosome [IDA]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [IDA]
- recycling endosome [IDA]
- tertiary granule [IDA]
- vesicle [IDA]
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The endolysosomal adaptor PLEKHM1 is a direct target for both mTOR and MAPK pathways.
The lysosome is a cellular signalling hub at the point of convergence of endocytic and autophagic pathways, where the contents are degraded and recycled. Pleckstrin homology domain-containing family member 1 (PLEKHM1) acts as an adaptor to facilitate the fusion of endocytic and autophagic vesicles with the lysosome. However, it is unclear how PLEKHM1 function at the lysosome is controlled. Herein, ... [more]
FEBS Lett Apr. 01, 2021; 595(7);864-880 [Pubmed: 33452816]
Throughput
- High Throughput
Curated By
- BioGRID