BAIT
PLEKHM1
AP162, B2, OPTB6
pleckstrin homology domain containing, family M (with RUN domain) member 1
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY
SEC13
D3S1231E, SEC13L1, SEC13R, npp-20
SEC13 homolog (S. cerevisiae)
GO Process (10)
GO Function (1)
GO Component (8)
Gene Ontology Biological Process
- COPII vesicle coating [TAS]
- ER to Golgi vesicle-mediated transport [TAS]
- antigen processing and presentation of exogenous peptide antigen via MHC class II [TAS]
- antigen processing and presentation of peptide antigen via MHC class I [TAS]
- cellular protein metabolic process [TAS]
- intracellular protein transport [NAS]
- membrane organization [TAS]
- mitotic cell cycle [TAS]
- post-translational protein modification [TAS]
- protein N-linked glycosylation via asparagine [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The endolysosomal adaptor PLEKHM1 is a direct target for both mTOR and MAPK pathways.
The lysosome is a cellular signalling hub at the point of convergence of endocytic and autophagic pathways, where the contents are degraded and recycled. Pleckstrin homology domain-containing family member 1 (PLEKHM1) acts as an adaptor to facilitate the fusion of endocytic and autophagic vesicles with the lysosome. However, it is unclear how PLEKHM1 function at the lysosome is controlled. Herein, ... [more]
FEBS Lett Apr. 01, 2021; 595(7);864-880 [Pubmed: 33452816]
Throughput
- High Throughput
Curated By
- BioGRID