APP
Gene Ontology Biological Process
- adult locomotory behavior [ISO, ISS]
- axon cargo transport [ISO, ISS]
- axon midline choice point recognition [ISO, ISS]
- axonogenesis [ISO, ISS]
- cellular copper ion homeostasis [ISO, ISS]
- cholesterol metabolic process [ISO]
- collateral sprouting in absence of injury [ISO, ISS]
- dendrite development [ISO, ISS]
- endocytosis [ISO, ISS]
- extracellular matrix organization [ISO, ISS]
- forebrain development [ISO]
- ionotropic glutamate receptor signaling pathway [ISO, ISS]
- locomotory behavior [ISO, ISS]
- mRNA polyadenylation [ISO, ISS]
- mating behavior [ISO, ISS]
- negative regulation of endopeptidase activity [ISO]
- negative regulation of neuron differentiation [ISO]
- neuromuscular process controlling balance [ISO]
- neuron apoptotic process [ISO]
- neuron projection development [ISO, ISS]
- neuron remodeling [ISO, ISS]
- positive regulation of G2/M transition of mitotic cell cycle [ISO]
- positive regulation of mitotic cell cycle [ISO, ISS]
- positive regulation of peptidase activity [IDA]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- protein phosphorylation [ISO, ISS]
- regulation of epidermal growth factor-activated receptor activity [ISO, ISS]
- regulation of gene expression [ISO]
- regulation of multicellular organism growth [ISO, ISS]
- regulation of protein binding [ISO]
- regulation of synapse structure or activity [ISO, ISS]
- regulation of translation [ISO, ISS]
- response to oxidative stress [ISO]
- smooth endoplasmic reticulum calcium ion homeostasis [ISO]
- suckling behavior [ISO]
- synaptic growth at neuromuscular junction [ISO]
- visual learning [ISO, ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- ER to Golgi transport vesicle [ISO]
- Golgi apparatus [IDA, ISO, ISS]
- apical part of cell [ISO]
- axon [IDA, ISO, ISS]
- cell [ISO]
- cell surface [IDA, ISO]
- cell-cell junction [ISO]
- ciliary rootlet [ISO]
- cytoplasm [ISO, ISS]
- cytoplasmic vesicle [ISO]
- dendritic shaft [ISO]
- dendritic spine [ISO]
- endosome [ISO]
- extracellular space [ISO]
- extracellular vesicular exosome [ISO]
- integral component of membrane [ISO, ISS]
- intracellular [ISO]
- intracellular membrane-bounded organelle [ISO]
- membrane [ISO]
- membrane raft [ISO]
- neuromuscular junction [ISO]
- neuron projection [IDA, ISO]
- nuclear envelope lumen [ISO]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [ISO]
- receptor complex [ISO]
- smooth endoplasmic reticulum [ISO]
- spindle midzone [ISO]
- synapse [ISO]
- synaptic vesicle [IDA]
- terminal bouton [IDA]
PPP1CC
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Identification of a novel complex A?PP:Fe65:PP1 that regulates A?PP Thr668 phosphorylation levels.
The amyloid-? protein precursor (A?PP) binds several proteins determining metabolism, processing, and the physiological fate of the former. Among these is Fe65, a protein with specific functional significance for A?PP, in particular conferring stability when the latter is dephosphorylated on Thr668. Thus, it follows that phosphatases like protein phosphatase 1 (PP1) are relevant to A?PP processing. Consequently, the identification of ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PPP1CC APP | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID