APBB1
Gene Ontology Biological Process
- axon guidance [ISO]
- cell cycle arrest [ISO, ISS]
- cellular response to DNA damage stimulus [ISO]
- double-strand break repair [IMP, ISO]
- extracellular matrix organization [ISO]
- histone H4 acetylation [IMP]
- negative regulation of cell growth [ISO, ISS]
- negative regulation of neuron differentiation [ISO]
- negative regulation of thymidylate synthase biosynthetic process [ISO, ISS]
- neuron migration [ISO]
- positive regulation of DNA repair [IMP, ISO]
- positive regulation of apoptotic process [ISO, ISS]
- positive regulation of protein secretion [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- positive regulation of transcription, DNA-templated [IDA, ISO]
- regulation of transcription, DNA-templated [ISO, ISS]
- response to iron ion [IEP]
- visual learning [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PPP1CC
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Identification of a novel complex A?PP:Fe65:PP1 that regulates A?PP Thr668 phosphorylation levels.
The amyloid-? protein precursor (A?PP) binds several proteins determining metabolism, processing, and the physiological fate of the former. Among these is Fe65, a protein with specific functional significance for A?PP, in particular conferring stability when the latter is dephosphorylated on Thr668. Thus, it follows that phosphatases like protein phosphatase 1 (PP1) are relevant to A?PP processing. Consequently, the identification of ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PPP1CC APBB1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID