DDR2
Gene Ontology Biological Process
- biomineral tissue development [ISS]
- chondrocyte proliferation [ISS, TAS]
- collagen fibril organization [ISS]
- collagen-activated tyrosine kinase receptor signaling pathway [IDA]
- endochondral bone growth [ISS]
- extracellular matrix organization [TAS]
- peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of extracellular matrix disassembly [ISS]
- positive regulation of fibroblast migration [ISS, TAS]
- positive regulation of fibroblast proliferation [ISS]
- positive regulation of osteoblast differentiation [IMP]
- positive regulation of protein kinase activity [IMP]
- positive regulation of sequence-specific DNA binding transcription factor activity [IMP]
- protein autophosphorylation [IDA]
- regulation of bone mineralization [IMP]
- regulation of extracellular matrix disassembly [TAS]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
TFRC
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- blood microparticle [IDA]
- cell surface [IDA]
- coated pit [IDA]
- cytoplasmic membrane-bounded vesicle [IDA]
- endosome [IDA]
- extracellular region [IDA]
- extracellular space [IDA]
- extracellular vesicular exosome [IDA]
- integral component of plasma membrane [TAS]
- intracellular membrane-bounded organelle [IDA]
- membrane [NAS]
- plasma membrane [TAS]
- recycling endosome [IDA]
- vesicle [IDA]
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Physical and functional interactome atlas of human receptor tyrosine kinases.
Much cell-to-cell communication is facilitated by cell surface receptor tyrosine kinases (RTKs). These proteins phosphorylate their downstream cytoplasmic substrates in response to stimuli such as growth factors. Despite their central roles, the functions of many RTKs are still poorly understood. To resolve the lack of systematic knowledge, we apply three complementary methods to map the molecular context and substrate profiles ... [more]
Quantitative Score
- 0.0 [BFDR Score]
Throughput
- High Throughput
Additional Notes
- Proximity Label-MS was carried out to identify high confidence protein interactors with a BFDR of less than or equal to 0.05 (BFDR score reported)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| DDR2 TFRC | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.02 | BioGRID | 3505789 |
Curated By
- BioGRID