BAIT
EPHB2
CAPB, DRT, EK5, EPHT3, ERK, Hek5, PCBC, Tyro5
EPH receptor B2
GO Process (16)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
- angiogenesis [ISS]
- axon guidance [ISS, TAS]
- axonal fasciculation [ISS]
- commissural neuron axon guidance [ISS]
- corpus callosum development [ISS]
- dendritic spine development [ISS]
- dendritic spine morphogenesis [ISS]
- ephrin receptor signaling pathway [ISS]
- inner ear morphogenesis [ISS]
- nervous system development [TAS]
- palate development [ISS]
- peptidyl-tyrosine phosphorylation [ISS]
- phosphorylation [ISS]
- positive regulation of synapse assembly [ISS]
- regulation of body fluid levels [ISS]
- urogenital system development [ISS]
Gene Ontology Molecular Function
Homo sapiens
PREY
ANK3
ANKYRIN-G, MRT37, RP11-369L1.1
ankyrin 3, node of Ranvier (ankyrin G)
GO Process (17)
GO Function (7)
GO Component (14)
Gene Ontology Biological Process
- Golgi to plasma membrane protein transport [IMP]
- axonogenesis [ISS]
- cytoskeletal anchoring at plasma membrane [TAS]
- establishment of protein localization [IMP]
- maintenance of protein location in plasma membrane [IGI]
- membrane assembly [IMP]
- mitotic cytokinesis [IMP]
- neuronal action potential [ISS]
- plasma membrane organization [IMP]
- positive regulation of gene expression [ISS]
- positive regulation of membrane depolarization during cardiac muscle cell action potential [ISS]
- positive regulation of membrane potential [ISS]
- positive regulation of sodium ion transmembrane transporter activity [ISS]
- positive regulation of sodium ion transport [ISS]
- protein localization to plasma membrane [IGI, IMP]
- protein targeting to plasma membrane [IMP]
- regulation of potassium ion transport [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- T-tubule [ISS]
- axon initial segment [ISS]
- basal plasma membrane [IDA]
- basolateral plasma membrane [IDA]
- cell surface [ISS]
- costamere [TAS]
- endoplasmic reticulum [TAS]
- intercalated disc [ISS]
- lateral plasma membrane [IDA]
- node of Ranvier [ISS]
- plasma membrane [ISS]
- sarcolemma [IDA]
- spectrin-associated cytoskeleton [ISS]
- tight junction [IDA]
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Physical and functional interactome atlas of human receptor tyrosine kinases.
Much cell-to-cell communication is facilitated by cell surface receptor tyrosine kinases (RTKs). These proteins phosphorylate their downstream cytoplasmic substrates in response to stimuli such as growth factors. Despite their central roles, the functions of many RTKs are still poorly understood. To resolve the lack of systematic knowledge, we apply three complementary methods to map the molecular context and substrate profiles ... [more]
EMBO Rep Jun. 07, 2022; 23(6);e54041 [Pubmed: 35384245]
Quantitative Score
- 0.02 [BFDR Score]
Throughput
- High Throughput
Additional Notes
- Proximity Label-MS was carried out to identify high confidence protein interactors with a BFDR of less than or equal to 0.05 (BFDR score reported)
Curated By
- BioGRID