BAIT
EPHB2
CAPB, DRT, EK5, EPHT3, ERK, Hek5, PCBC, Tyro5
EPH receptor B2
GO Process (16)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
- angiogenesis [ISS]
- axon guidance [ISS, TAS]
- axonal fasciculation [ISS]
- commissural neuron axon guidance [ISS]
- corpus callosum development [ISS]
- dendritic spine development [ISS]
- dendritic spine morphogenesis [ISS]
- ephrin receptor signaling pathway [ISS]
- inner ear morphogenesis [ISS]
- nervous system development [TAS]
- palate development [ISS]
- peptidyl-tyrosine phosphorylation [ISS]
- phosphorylation [ISS]
- positive regulation of synapse assembly [ISS]
- regulation of body fluid levels [ISS]
- urogenital system development [ISS]
Gene Ontology Molecular Function
Homo sapiens
PREY
ANK2
ANK-2, LQT4, brank-2
ankyrin 2, neuronal
GO Process (36)
GO Function (7)
GO Component (11)
Gene Ontology Biological Process
- SA node cell action potential [ISS]
- SA node cell to atrial cardiac muscle cell communication [IMP]
- T-tubule organization [ISS]
- atrial cardiac muscle cell action potential [IMP]
- atrial cardiac muscle cell to AV node cell communication [ISS]
- atrial septum development [IMP]
- axon guidance [TAS]
- cellular calcium ion homeostasis [ISS]
- cellular protein localization [IGI]
- membrane depolarization during SA node cell action potential [TAS]
- positive regulation of calcium ion transmembrane transporter activity [ISS]
- positive regulation of calcium ion transport [ISS]
- positive regulation of cation channel activity [ISS]
- positive regulation of gene expression [IGI]
- positive regulation of potassium ion transmembrane transporter activity [ISS]
- positive regulation of potassium ion transport [ISS]
- protein localization to M-band [ISS]
- protein localization to T-tubule [ISS]
- protein localization to cell surface [ISS]
- protein localization to endoplasmic reticulum [IGI]
- protein localization to organelle [IGI]
- protein localization to plasma membrane [IGI, ISS]
- protein stabilization [ISS]
- regulation of calcium ion transmembrane transporter activity [ISS]
- regulation of calcium ion transport [IGI]
- regulation of cardiac muscle cell contraction [IGI]
- regulation of cardiac muscle contraction [IMP]
- regulation of cardiac muscle contraction by calcium ion signaling [IMP]
- regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [IGI, ISS]
- regulation of heart rate [IMP]
- regulation of heart rate by cardiac conduction [IMP, ISS]
- regulation of protein stability [IC]
- regulation of release of sequestered calcium ion into cytosol [IGI]
- regulation of ventricular cardiac muscle cell membrane repolarization [IMP]
- sarcoplasmic reticulum calcium ion transport [TAS]
- ventricular cardiac muscle cell action potential [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Physical and functional interactome atlas of human receptor tyrosine kinases.
Much cell-to-cell communication is facilitated by cell surface receptor tyrosine kinases (RTKs). These proteins phosphorylate their downstream cytoplasmic substrates in response to stimuli such as growth factors. Despite their central roles, the functions of many RTKs are still poorly understood. To resolve the lack of systematic knowledge, we apply three complementary methods to map the molecular context and substrate profiles ... [more]
EMBO Rep Jun. 07, 2022; 23(6);e54041 [Pubmed: 35384245]
Quantitative Score
- 0.04 [BFDR Score]
Throughput
- High Throughput
Additional Notes
- Proximity Label-MS was carried out to identify high confidence protein interactors with a BFDR of less than or equal to 0.05 (BFDR score reported)
Curated By
- BioGRID