BAIT
LTK
TYK1
leukocyte receptor tyrosine kinase
GO Process (9)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
- cell proliferation [IDA]
- cellular response to retinoic acid [IMP]
- negative regulation of apoptotic process [IMP]
- peptidyl-tyrosine phosphorylation [TAS]
- phosphatidylinositol 3-kinase signaling [IMP]
- positive regulation of cardiac muscle cell apoptotic process [IDA]
- positive regulation of neuron projection development [IMP]
- protein phosphorylation [IDA]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PARP1
ADPRT, ADPRT 1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1, RP11-125A15.2
poly (ADP-ribose) polymerase 1
GO Process (12)
GO Function (7)
GO Component (6)
Gene Ontology Biological Process
- DNA repair [TAS]
- cellular response to insulin stimulus [IDA]
- double-strand break repair [IMP]
- gene expression [TAS]
- macrophage differentiation [TAS]
- negative regulation of transcription from RNA polymerase II promoter [TAS]
- protein ADP-ribosylation [IDA]
- protein poly-ADP-ribosylation [IDA]
- transcription from RNA polymerase II promoter [TAS]
- transcription initiation from RNA polymerase II promoter [TAS]
- transcription, DNA-templated [TAS]
- transforming growth factor beta receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Physical and functional interactome atlas of human receptor tyrosine kinases.
Much cell-to-cell communication is facilitated by cell surface receptor tyrosine kinases (RTKs). These proteins phosphorylate their downstream cytoplasmic substrates in response to stimuli such as growth factors. Despite their central roles, the functions of many RTKs are still poorly understood. To resolve the lack of systematic knowledge, we apply three complementary methods to map the molecular context and substrate profiles ... [more]
EMBO Rep Jun. 07, 2022; 23(6);e54041 [Pubmed: 35384245]
Quantitative Score
- 0.02 [BFDR Score]
Throughput
- High Throughput
Additional Notes
- Affinity Capture-MS was carried out to identify high confidence protein interactors with a BFDR of less than or equal to 0.05 (BFDR score reported)
Curated By
- BioGRID