DDR2
Gene Ontology Biological Process
- biomineral tissue development [ISS]
- chondrocyte proliferation [ISS, TAS]
- collagen fibril organization [ISS]
- collagen-activated tyrosine kinase receptor signaling pathway [IDA]
- endochondral bone growth [ISS]
- extracellular matrix organization [TAS]
- peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of extracellular matrix disassembly [ISS]
- positive regulation of fibroblast migration [ISS, TAS]
- positive regulation of fibroblast proliferation [ISS]
- positive regulation of osteoblast differentiation [IMP]
- positive regulation of protein kinase activity [IMP]
- positive regulation of sequence-specific DNA binding transcription factor activity [IMP]
- protein autophosphorylation [IDA]
- regulation of bone mineralization [IMP]
- regulation of extracellular matrix disassembly [TAS]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PRKDC
Gene Ontology Biological Process
- DNA repair [TAS]
- cellular protein modification process [TAS]
- cellular response to insulin stimulus [IMP]
- double-strand break repair [TAS]
- double-strand break repair via homologous recombination [IBA]
- double-strand break repair via nonhomologous end joining [TAS]
- innate immune response [TAS]
- negative regulation of protein phosphorylation [ISS]
- peptidyl-serine phosphorylation [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of type I interferon production [TAS]
- regulation of circadian rhythm [ISS]
- signal transduction involved in mitotic G1 DNA damage checkpoint [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Physical and functional interactome atlas of human receptor tyrosine kinases.
Much cell-to-cell communication is facilitated by cell surface receptor tyrosine kinases (RTKs). These proteins phosphorylate their downstream cytoplasmic substrates in response to stimuli such as growth factors. Despite their central roles, the functions of many RTKs are still poorly understood. To resolve the lack of systematic knowledge, we apply three complementary methods to map the molecular context and substrate profiles ... [more]
Quantitative Score
- 0.02 [BFDR Score]
Throughput
- High Throughput
Additional Notes
- Affinity Capture-MS was carried out to identify high confidence protein interactors with a BFDR of less than or equal to 0.05 (BFDR score reported)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| DDR2 PRKDC | Proximity Label-MS Proximity Label-MS An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods. | High | 0 | BioGRID | 3505354 |
Curated By
- BioGRID