BAIT
EPHA5
CEK7, EHK-1, EHK1, EK7, HEK7, TYRO4
EPH receptor A5
GO Process (9)
GO Function (3)
GO Component (6)
Gene Ontology Biological Process
- axon guidance [ISS]
- cAMP-mediated signaling [ISS]
- ephrin receptor signaling pathway [ISS]
- hippocampus development [ISS]
- neuron development [IEP]
- positive regulation of CREB transcription factor activity [ISS]
- regulation of Rac GTPase activity [ISS]
- regulation of actin cytoskeleton organization [ISS]
- regulation of insulin secretion involved in cellular response to glucose stimulus [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
HADHA
ECHA, GBP, HADH, LCEH, LCHAD, MTPA, TP-ALPHA
hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
GO Process (6)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Physical and functional interactome atlas of human receptor tyrosine kinases.
Much cell-to-cell communication is facilitated by cell surface receptor tyrosine kinases (RTKs). These proteins phosphorylate their downstream cytoplasmic substrates in response to stimuli such as growth factors. Despite their central roles, the functions of many RTKs are still poorly understood. To resolve the lack of systematic knowledge, we apply three complementary methods to map the molecular context and substrate profiles ... [more]
EMBO Rep Jun. 07, 2022; 23(6);e54041 [Pubmed: 35384245]
Quantitative Score
- 0.0 [BFDR Score]
Throughput
- High Throughput
Additional Notes
- Affinity Capture-MS was carried out to identify high confidence protein interactors with a BFDR of less than or equal to 0.05 (BFDR score reported)
Curated By
- BioGRID