BAIT
EPHA4
HEK8, SEK, TYRO1
EPH receptor A4
GO Process (13)
GO Function (6)
GO Component (5)
Gene Ontology Biological Process
- corticospinal tract morphogenesis [ISS]
- fasciculation of motor neuron axon [ISS]
- fasciculation of sensory neuron axon [ISS]
- motor neuron axon guidance [ISS]
- negative regulation of axon regeneration [ISS]
- peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of Rho guanyl-nucleotide exchange factor activity [IDA]
- protein autophosphorylation [IDA]
- regulation of Rac GTPase activity [ISS]
- regulation of Rap GTPase activity [ISS]
- regulation of astrocyte differentiation [ISS]
- regulation of axonogenesis [ISS]
- regulation of dendritic spine morphogenesis [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
LTF
GIG12, HEL110, HLF2, LF
lactotransferrin
GO Process (25)
GO Function (5)
GO Component (7)
Gene Ontology Biological Process
- antibacterial humoral response [IDA]
- antifungal humoral response [IDA]
- bone morphogenesis [IDA]
- humoral immune response [TAS]
- innate immune response in mucosa [IDA]
- interaction with host [TAS]
- iron assimilation by chelation and transport [TAS]
- negative regulation of apoptotic process [ISS]
- negative regulation of lipopolysaccharide-mediated signaling pathway [IDA]
- negative regulation of osteoclast development [ISS]
- negative regulation of single-species biofilm formation in or on host organism [IDA]
- negative regulation of tumor necrosis factor (ligand) superfamily member 11 production [ISS]
- phagosome maturation [TAS]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- positive regulation of NF-kappaB transcription factor activity [IDA]
- positive regulation of bone mineralization involved in bone maturation [ISS]
- positive regulation of chondrocyte proliferation [IDA]
- positive regulation of osteoblast differentiation [IDA]
- positive regulation of osteoblast proliferation [IDA]
- positive regulation of protein serine/threonine kinase activity [IDA]
- positive regulation of toll-like receptor 4 signaling pathway [IMP]
- regulation of cytokine production [IDA]
- regulation of tumor necrosis factor production [IDA]
- response to host immune response [TAS]
- retina homeostasis [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Physical and functional interactome atlas of human receptor tyrosine kinases.
Much cell-to-cell communication is facilitated by cell surface receptor tyrosine kinases (RTKs). These proteins phosphorylate their downstream cytoplasmic substrates in response to stimuli such as growth factors. Despite their central roles, the functions of many RTKs are still poorly understood. To resolve the lack of systematic knowledge, we apply three complementary methods to map the molecular context and substrate profiles ... [more]
EMBO Rep Jun. 07, 2022; 23(6);e54041 [Pubmed: 35384245]
Quantitative Score
- 0.01 [BFDR Score]
Throughput
- High Throughput
Additional Notes
- Proximity Label-MS was carried out to identify high confidence protein interactors with a BFDR of less than or equal to 0.05 (BFDR score reported)
Curated By
- BioGRID