EPHA2
Gene Ontology Biological Process
- activation of Rac GTPase activity [IMP]
- bone remodeling [ISS]
- branching involved in mammary gland duct morphogenesis [ISS]
- cell chemotaxis [IMP]
- cell migration [IMP]
- ephrin receptor signaling pathway [IDA]
- intrinsic apoptotic signaling pathway in response to DNA damage [IDA]
- keratinocyte differentiation [IMP]
- lens fiber cell morphogenesis [ISS]
- mammary gland epithelial cell proliferation [ISS]
- multicellular organismal development [TAS]
- negative regulation of protein kinase B signaling [IDA]
- osteoblast differentiation [ISS]
- osteoclast differentiation [ISS]
- peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of establishment of protein localization to plasma membrane [IMP]
- protein kinase B signaling [IDA]
- regulation of ERK1 and ERK2 cascade [IMP]
- regulation of angiogenesis [ISS]
- regulation of blood vessel endothelial cell migration [ISS]
- regulation of cell adhesion mediated by integrin [IDA]
- regulation of lamellipodium assembly [IMP]
- response to growth factor [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
FLOT2
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Physical and functional interactome atlas of human receptor tyrosine kinases.
Much cell-to-cell communication is facilitated by cell surface receptor tyrosine kinases (RTKs). These proteins phosphorylate their downstream cytoplasmic substrates in response to stimuli such as growth factors. Despite their central roles, the functions of many RTKs are still poorly understood. To resolve the lack of systematic knowledge, we apply three complementary methods to map the molecular context and substrate profiles ... [more]
Quantitative Score
- 0.02 [BFDR Score]
Throughput
- High Throughput
Additional Notes
- Proximity Label-MS was carried out to identify high confidence protein interactors with a BFDR of less than or equal to 0.05 (BFDR score reported)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| EPHA2 FLOT2 | Proximity Label-MS Proximity Label-MS An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods. | High | - | BioGRID | 3730852 |
Curated By
- BioGRID