BAIT
EPHA1
EPH, EPHT, EPHT1
EPH receptor A1
GO Process (13)
GO Function (3)
GO Component (1)
Gene Ontology Biological Process
- activation of Rho GTPase activity [IDA]
- cell surface receptor signaling pathway [IDA]
- negative regulation of cell migration [IDA]
- negative regulation of protein kinase activity [IDA]
- peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of angiogenesis [IMP]
- positive regulation of cell migration [IMP]
- positive regulation of cell proliferation [IMP]
- positive regulation of cell-matrix adhesion [IDA]
- positive regulation of stress fiber assembly [ISS]
- protein autophosphorylation [IDA]
- regulation of Rac GTPase activity [IDA]
- substrate adhesion-dependent cell spreading [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
RPS23
S23
ribosomal protein S23
GO Process (13)
GO Function (2)
GO Component (6)
Gene Ontology Biological Process
- RNA metabolic process [TAS]
- SRP-dependent cotranslational protein targeting to membrane [TAS]
- cellular protein metabolic process [TAS]
- gene expression [TAS]
- mRNA metabolic process [TAS]
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [TAS]
- translation [IC, TAS]
- translational elongation [TAS]
- translational initiation [TAS]
- translational termination [TAS]
- viral life cycle [TAS]
- viral process [TAS]
- viral transcription [TAS]
Gene Ontology Molecular Function
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Physical and functional interactome atlas of human receptor tyrosine kinases.
Much cell-to-cell communication is facilitated by cell surface receptor tyrosine kinases (RTKs). These proteins phosphorylate their downstream cytoplasmic substrates in response to stimuli such as growth factors. Despite their central roles, the functions of many RTKs are still poorly understood. To resolve the lack of systematic knowledge, we apply three complementary methods to map the molecular context and substrate profiles ... [more]
EMBO Rep Jun. 07, 2022; 23(6);e54041 [Pubmed: 35384245]
Quantitative Score
- 0.02 [BFDR Score]
Throughput
- High Throughput
Additional Notes
- Proximity Label-MS was carried out to identify high confidence protein interactors with a BFDR of less than or equal to 0.05 (BFDR score reported)
Curated By
- BioGRID