BAIT
EPHA8
EEK, EK3, HEK3, RP1-61A9.3
EPH receptor A8
GO Process (10)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
- axon guidance [ISS]
- ephrin receptor signaling pathway [ISS]
- neuron projection development [ISS]
- neuron remodeling [ISS]
- positive regulation of MAPK cascade [ISS]
- positive regulation of phosphatidylinositol 3-kinase activity [ISS]
- protein autophosphorylation [ISS]
- regulation of cell adhesion [ISS]
- regulation of cell adhesion mediated by integrin [ISS]
- substrate-dependent cell migration [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
UCHL1
HEL-117, NDGOA, PARK5, PGP 9.5, PGP9.5, PGP95, Uch-L1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
GO Process (3)
GO Function (6)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Physical and functional interactome atlas of human receptor tyrosine kinases.
Much cell-to-cell communication is facilitated by cell surface receptor tyrosine kinases (RTKs). These proteins phosphorylate their downstream cytoplasmic substrates in response to stimuli such as growth factors. Despite their central roles, the functions of many RTKs are still poorly understood. To resolve the lack of systematic knowledge, we apply three complementary methods to map the molecular context and substrate profiles ... [more]
EMBO Rep Jun. 07, 2022; 23(6);e54041 [Pubmed: 35384245]
Quantitative Score
- 0.02 [BFDR Score]
Throughput
- High Throughput
Additional Notes
- Affinity Capture-MS was carried out to identify high confidence protein interactors with a BFDR of less than or equal to 0.05 (BFDR score reported)
Curated By
- BioGRID