BAIT
RET
CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET-ELE1, RET51
ret proto-oncogene
GO Process (18)
GO Function (4)
GO Component (6)
Gene Ontology Biological Process
- Peyer's patch morphogenesis [ISS]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- cellular response to retinoic acid [IMP]
- lymphocyte migration into lymphoid organs [ISS]
- membrane protein proteolysis [IDA]
- neuron cell-cell adhesion [IMP]
- peptidyl-tyrosine phosphorylation [TAS]
- positive regulation of cell adhesion mediated by integrin [IDA]
- positive regulation of cell migration [IDA]
- positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [IMP, TAS]
- positive regulation of metanephric glomerulus development [ISS]
- positive regulation of neuron projection development [IMP]
- positive regulation of transcription, DNA-templated [ISS]
- posterior midgut development [TAS]
- protein phosphorylation [TAS]
- regulation of cell adhesion [IDA]
- response to pain [ISS]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SEC31A
ABP125, ABP130, HSPC334, SEC31L1, HSPC275
SEC31 homolog A (S. cerevisiae)
GO Process (11)
GO Function (2)
GO Component (12)
Gene Ontology Biological Process
- COPII vesicle coating [TAS]
- ER to Golgi vesicle-mediated transport [NAS, TAS]
- activation of signaling protein activity involved in unfolded protein response [TAS]
- antigen processing and presentation of exogenous peptide antigen via MHC class II [TAS]
- antigen processing and presentation of peptide antigen via MHC class I [TAS]
- cellular protein metabolic process [TAS]
- endoplasmic reticulum unfolded protein response [TAS]
- membrane organization [TAS]
- post-translational protein modification [TAS]
- protein N-linked glycosylation via asparagine [TAS]
- response to calcium ion [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- COPII vesicle coat [NAS]
- ER to Golgi transport vesicle [IDA]
- ER to Golgi transport vesicle membrane [TAS]
- Golgi membrane [TAS]
- cytoplasm [IDA]
- cytosol [TAS]
- endoplasmic reticulum [IDA]
- endoplasmic reticulum exit site [IMP]
- endoplasmic reticulum membrane [TAS]
- intracellular membrane-bounded organelle [IDA]
- perinuclear region of cytoplasm [IDA]
- vesicle coat [IDA]
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Physical and functional interactome atlas of human receptor tyrosine kinases.
Much cell-to-cell communication is facilitated by cell surface receptor tyrosine kinases (RTKs). These proteins phosphorylate their downstream cytoplasmic substrates in response to stimuli such as growth factors. Despite their central roles, the functions of many RTKs are still poorly understood. To resolve the lack of systematic knowledge, we apply three complementary methods to map the molecular context and substrate profiles ... [more]
EMBO Rep Jun. 07, 2022; 23(6);e54041 [Pubmed: 35384245]
Quantitative Score
- 0.0 [BFDR Score]
Throughput
- High Throughput
Additional Notes
- Proximity Label-MS was carried out to identify high confidence protein interactors with a BFDR of less than or equal to 0.05 (BFDR score reported)
Curated By
- BioGRID