ERBB3
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- Schwann cell differentiation [ISS]
- cranial nerve development [ISS]
- epidermal growth factor receptor signaling pathway [TAS]
- extrinsic apoptotic signaling pathway in absence of ligand [IMP]
- fibroblast growth factor receptor signaling pathway [TAS]
- heart development [ISS]
- innate immune response [TAS]
- negative regulation of cell adhesion [IDA]
- negative regulation of neuron apoptotic process [ISS]
- negative regulation of secretion [IDA]
- negative regulation of signal transduction [IDA]
- neuron apoptotic process [IMP]
- neurotrophin TRK receptor signaling pathway [TAS]
- peripheral nervous system development [ISS]
- phosphatidylinositol 3-kinase signaling [IDA]
- phosphatidylinositol-mediated signaling [TAS]
- positive regulation of phosphatidylinositol 3-kinase signaling [TAS]
- positive regulation of protein tyrosine kinase activity [IMP]
- regulation of cell proliferation [IDA]
- signal transduction [IDA]
- transmembrane receptor protein tyrosine kinase signaling pathway [ISS]
- wound healing [NAS]
Gene Ontology Molecular Function- growth factor binding [IPI, ISS]
- identical protein binding [IPI]
- protein binding [IPI]
- protein heterodimerization activity [IDA, IPI]
- protein homodimerization activity [NAS]
- protein tyrosine kinase activator activity [IDA]
- protein tyrosine kinase activity [IDA]
- transmembrane signaling receptor activity [ISS]
- growth factor binding [IPI, ISS]
- identical protein binding [IPI]
- protein binding [IPI]
- protein heterodimerization activity [IDA, IPI]
- protein homodimerization activity [NAS]
- protein tyrosine kinase activator activity [IDA]
- protein tyrosine kinase activity [IDA]
- transmembrane signaling receptor activity [ISS]
Gene Ontology Cellular Component
HGS
Gene Ontology Biological Process
- endosomal transport [NAS, TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- membrane invagination [IMP]
- membrane organization [TAS]
- negative regulation of JAK-STAT cascade [IDA]
- negative regulation of cell proliferation [TAS]
- negative regulation of epidermal growth factor receptor signaling pathway [TAS]
- positive regulation of exosomal secretion [IMP]
- positive regulation of gene expression [IMP]
- protein localization to membrane [IMP]
- protein targeting to lysosome [IMP]
- regulation of protein catabolic process [TAS]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Physical and functional interactome atlas of human receptor tyrosine kinases.
Much cell-to-cell communication is facilitated by cell surface receptor tyrosine kinases (RTKs). These proteins phosphorylate their downstream cytoplasmic substrates in response to stimuli such as growth factors. Despite their central roles, the functions of many RTKs are still poorly understood. To resolve the lack of systematic knowledge, we apply three complementary methods to map the molecular context and substrate profiles ... [more]
Quantitative Score
- 0.03 [BFDR Score]
Throughput
- High Throughput
Additional Notes
- Proximity Label-MS was carried out to identify high confidence protein interactors with a BFDR of less than or equal to 0.05 (BFDR score reported)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| ERBB3 HGS | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| HGS ERBB3 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID