BAIT
FLT4
FLT41, LMPH1A, PCL, VEGFR3
fms-related tyrosine kinase 4
GO Process (22)
GO Function (5)
GO Component (2)
Gene Ontology Biological Process
- blood vessel morphogenesis [ISS]
- cellular response to vascular endothelial growth factor stimulus [IDA, IMP]
- lymph vessel development [ISS]
- lymphangiogenesis [IMP, ISS]
- negative regulation of apoptotic process [IMP]
- peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of ERK1 and ERK2 cascade [IMP]
- positive regulation of JNK cascade [IMP]
- positive regulation of MAPK cascade [IMP]
- positive regulation of cell proliferation [IGI, IMP]
- positive regulation of endothelial cell migration [IMP]
- positive regulation of endothelial cell proliferation [IMP]
- positive regulation of protein kinase C signaling [IMP]
- positive regulation of protein phosphorylation [IMP]
- positive regulation vascular endothelial growth factor production [IMP]
- protein autophosphorylation [IDA]
- regulation of blood vessel remodeling [ISS]
- sprouting angiogenesis [ISS]
- transmembrane receptor protein tyrosine kinase signaling pathway [TAS]
- vascular endothelial growth factor receptor signaling pathway [IDA, IGI, IMP, TAS]
- vascular endothelial growth factor signaling pathway [IDA, IMP, TAS]
- vasculature development [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PFKP
ATP-PFK, PFK-C, PFK-P, PFKF, RP11-298E9.2
phosphofructokinase, platelet
GO Process (5)
GO Function (2)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Physical and functional interactome atlas of human receptor tyrosine kinases.
Much cell-to-cell communication is facilitated by cell surface receptor tyrosine kinases (RTKs). These proteins phosphorylate their downstream cytoplasmic substrates in response to stimuli such as growth factors. Despite their central roles, the functions of many RTKs are still poorly understood. To resolve the lack of systematic knowledge, we apply three complementary methods to map the molecular context and substrate profiles ... [more]
EMBO Rep Jun. 07, 2022; 23(6);e54041 [Pubmed: 35384245]
Quantitative Score
- 0.0 [BFDR Score]
Throughput
- High Throughput
Additional Notes
- Affinity Capture-MS was carried out to identify high confidence protein interactors with a BFDR of less than or equal to 0.05 (BFDR score reported)
Curated By
- BioGRID