BAIT
FLT4
FLT41, LMPH1A, PCL, VEGFR3
fms-related tyrosine kinase 4
GO Process (22)
GO Function (5)
GO Component (2)
Gene Ontology Biological Process
- blood vessel morphogenesis [ISS]
- cellular response to vascular endothelial growth factor stimulus [IDA, IMP]
- lymph vessel development [ISS]
- lymphangiogenesis [IMP, ISS]
- negative regulation of apoptotic process [IMP]
- peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of ERK1 and ERK2 cascade [IMP]
- positive regulation of JNK cascade [IMP]
- positive regulation of MAPK cascade [IMP]
- positive regulation of cell proliferation [IGI, IMP]
- positive regulation of endothelial cell migration [IMP]
- positive regulation of endothelial cell proliferation [IMP]
- positive regulation of protein kinase C signaling [IMP]
- positive regulation of protein phosphorylation [IMP]
- positive regulation vascular endothelial growth factor production [IMP]
- protein autophosphorylation [IDA]
- regulation of blood vessel remodeling [ISS]
- sprouting angiogenesis [ISS]
- transmembrane receptor protein tyrosine kinase signaling pathway [TAS]
- vascular endothelial growth factor receptor signaling pathway [IDA, IGI, IMP, TAS]
- vascular endothelial growth factor signaling pathway [IDA, IMP, TAS]
- vasculature development [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SCFD1
C14orf163, RA410, SLY1, SLY1P, STXBP1L2, FKSG23
sec1 family domain containing 1
GO Process (8)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
- cell morphogenesis [ISS]
- negative regulation of autophagic vacuole assembly [IMP]
- phagocytosis [ISS]
- post-Golgi vesicle-mediated transport [ISS]
- regulation of ER to Golgi vesicle-mediated transport [ISS]
- regulation of protein transport [IMP]
- response to toxic substance [IEP]
- retrograde vesicle-mediated transport, Golgi to ER [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Physical and functional interactome atlas of human receptor tyrosine kinases.
Much cell-to-cell communication is facilitated by cell surface receptor tyrosine kinases (RTKs). These proteins phosphorylate their downstream cytoplasmic substrates in response to stimuli such as growth factors. Despite their central roles, the functions of many RTKs are still poorly understood. To resolve the lack of systematic knowledge, we apply three complementary methods to map the molecular context and substrate profiles ... [more]
EMBO Rep Jun. 07, 2022; 23(6);e54041 [Pubmed: 35384245]
Quantitative Score
- 0.01 [BFDR Score]
Throughput
- High Throughput
Additional Notes
- Proximity Label-MS was carried out to identify high confidence protein interactors with a BFDR of less than or equal to 0.05 (BFDR score reported)
Curated By
- BioGRID