FLT3
Gene Ontology Biological Process
- B cell differentiation [ISS]
- cellular response to cytokine stimulus [ISS, TAS]
- common myeloid progenitor cell proliferation [ISS]
- cytokine-mediated signaling pathway [ISS]
- dendritic cell differentiation [ISS]
- hemopoiesis [IDA]
- leukocyte homeostasis [ISS]
- lymphocyte proliferation [ISS]
- myeloid progenitor cell differentiation [ISS]
- peptidyl-tyrosine phosphorylation [TAS]
- positive regulation of MAP kinase activity [TAS]
- positive regulation of MAPK cascade [TAS]
- positive regulation of cell proliferation [TAS]
- positive regulation of phosphatidylinositol 3-kinase activity [TAS]
- positive regulation of phosphatidylinositol 3-kinase signaling [TAS]
- positive regulation of tyrosine phosphorylation of STAT protein [TAS]
- pro-B cell differentiation [ISS]
- protein autophosphorylation [TAS]
- regulation of apoptotic process [TAS]
- transmembrane receptor protein tyrosine kinase signaling pathway [TAS]
- vascular endothelial growth factor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PPAN
Gene Ontology Biological Process
Gene Ontology Molecular Function
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Physical and functional interactome atlas of human receptor tyrosine kinases.
Much cell-to-cell communication is facilitated by cell surface receptor tyrosine kinases (RTKs). These proteins phosphorylate their downstream cytoplasmic substrates in response to stimuli such as growth factors. Despite their central roles, the functions of many RTKs are still poorly understood. To resolve the lack of systematic knowledge, we apply three complementary methods to map the molecular context and substrate profiles ... [more]
Quantitative Score
- 0.01 [BFDR Score]
Throughput
- High Throughput
Additional Notes
- Proximity Label-MS was carried out to identify high confidence protein interactors with a BFDR of less than or equal to 0.05 (BFDR score reported)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| FLT3 PPAN | Positive Genetic Positive Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a less severe fitness defect than expected under a given condition. This term is reserved for high or low throughput studies with scores. | Low | - | BioGRID | 2547661 |
Curated By
- BioGRID