BAIT

C16ORF72

PRO0149
chromosome 16 open reading frame 72
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY

MTHFD1L

FTHFSDC1, MTC1THFS, dJ292B18.2, RP1-292B18.2
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

C16orf72/HAPSTR1 is a molecular rheostat in an integrated network of stress response pathways.

Amici DR, Ansel DJ, Metz KA, Smith RS, Phoumyvong CM, Gayatri S, Chamera T, Edwards SL, O'Hara BP, Srivastava S, Brockway S, Takagishi SR, Cho BK, Goo YA, Kelleher NL, Ben-Sahra I, Foltz DR, Li J, Mendillo ML

All cells contain specialized signaling pathways that enable adaptation to specific molecular stressors. Yet, whether these pathways are centrally regulated in complex physiological stress states remains unclear. Using genome-scale fitness screening data, we quantified the stress phenotype of 739 cancer cell lines, each representing a unique combination of intrinsic tumor stresses. Integrating dependency and stress perturbation transcriptomic data, we illuminated ... [more]

Proc Natl Acad Sci U S A Dec. 05, 2021; 119(27);e2111262119 [Pubmed: 35776542]

Throughput

  • High Throughput

Additional Notes

  • Interactions were determined to be high confidence if the log2FC spectra in the C16orf72 vs GFP IP-MS experiment was greater than 3 (log2FC > 3).

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
C16ORF72 MTHFD1L
Proximity Label-MS
Proximity Label-MS

An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.

High-BioGRID
3541388

Curated By

  • BioGRID