BAIT
IFNB1
IFB, IFF, IFNB, RP11-113D19.1
interferon, beta 1, fibroblast
GO Process (26)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
- B cell activation involved in immune response [IMP]
- B cell differentiation [IBA]
- B cell proliferation [NAS]
- T cell activation involved in immune response [IBA]
- blood coagulation [TAS]
- cell surface receptor signaling pathway [TAS]
- cellular response to exogenous dsRNA [TAS]
- cellular response to interferon-beta [IDA]
- cytokine-mediated signaling pathway [IBA, TAS]
- defense response to virus [TAS]
- humoral immune response [IBA]
- innate immune response [TAS]
- natural killer cell activation [NAS]
- natural killer cell activation involved in immune response [IBA]
- negative regulation of T cell differentiation [IDA]
- negative regulation of T-helper 2 cell cytokine production [IDA]
- negative regulation of viral genome replication [IDA]
- positive regulation of apoptotic signaling pathway [IDA]
- positive regulation of innate immune response [NAS]
- positive regulation of peptidyl-serine phosphorylation of STAT protein [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of MHC class I biosynthetic process [NAS]
- regulation of type I interferon-mediated signaling pathway [TAS]
- response to exogenous dsRNA [IDA]
- response to virus [NAS]
- type I interferon signaling pathway [IDA, TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
S100A4
18A2, 42A, CAPL, FSP1, MTS1, P9KA, PEL98
S100 calcium binding protein A4
GO Process (2)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Interferon Beta Activity Is Modulated via Binding of Specific S100 Proteins.
Interferon-? (IFN-?) is a pleiotropic cytokine used for therapy of multiple sclerosis, which is also effective in suppression of viral and bacterial infections and cancer. Recently, we reported a highly specific interaction between IFN-? and S100P lowering IFN-? cytotoxicity to cancer cells (Int J Biol Macromol. 2020; 143: 633-639). S100P is a member of large family of multifunctional Ca2+-binding proteins ... [more]
Int J Mol Sci Dec. 13, 2020; 21(24); [Pubmed: 33322098]
Throughput
- Low Throughput
Additional Notes
- Cell viability tests
Curated By
- BioGRID