ALK
Gene Ontology Biological Process
- NIK/NF-kappaB signaling [TAS]
- activation of MAPK activity [TAS]
- cell proliferation [TAS]
- neuron development [TAS]
- peptidyl-tyrosine phosphorylation [IDA, TAS]
- phosphorylation [IDA, TAS]
- positive regulation of NF-kappaB transcription factor activity [TAS]
- protein autophosphorylation [IDA, TAS]
- regulation of apoptotic process [TAS]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
HES1
Gene Ontology Biological Process
- Notch signaling pathway [IDA, IMP, TAS]
- STAT protein import into nucleus [ISS]
- artery morphogenesis [ISS]
- ascending aorta morphogenesis [ISS]
- cardiac neural crest cell development involved in outflow tract morphogenesis [ISS]
- embryonic heart tube morphogenesis [ISS]
- endocrine pancreas development [TAS]
- forebrain radial glial cell differentiation [ISS]
- negative regulation of forebrain neuron differentiation [ISS]
- negative regulation of glial cell proliferation [ISS]
- negative regulation of oligodendrocyte differentiation [ISS]
- negative regulation of pro-B cell differentiation [IMP]
- negative regulation of stem cell differentiation [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- nervous system development [TAS]
- neuronal stem cell maintenance [IEP]
- outflow tract morphogenesis [ISS]
- pharyngeal arch artery morphogenesis [ISS]
- positive regulation of DNA binding [ISS]
- positive regulation of JAK-STAT cascade [ISS]
- positive regulation of astrocyte differentiation [ISS]
- positive regulation of cell proliferation [ISS]
- positive regulation of mitotic cell cycle, embryonic [ISS]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
- positive regulation of tyrosine phosphorylation of Stat3 protein [ISS]
- protein complex assembly [ISS]
- regulation of secondary heart field cardioblast proliferation [ISS]
- thymus development [ISS]
- vascular smooth muscle cell development [ISS]
- ventricular septum development [ISS]
- ventricular septum morphogenesis [ISS]
Gene Ontology Molecular Function- DNA binding [TAS]
- N-box binding [ISS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [ISS]
- histone deacetylase binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [ISS]
- sequence-specific DNA binding [ISS]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [NAS]
- DNA binding [TAS]
- N-box binding [ISS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [ISS]
- histone deacetylase binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [ISS]
- sequence-specific DNA binding [ISS]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [NAS]
Gene Ontology Cellular Component
- nucleoplasm [IDA, TAS]
- nucleus [ISS]
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Induction of Transcriptional Inhibitor HES1 and the Related Repression of Tumor-Suppressor TXNIP Are Important Components of Cell-Transformation Program Imposed by Oncogenic Kinase NPM-ALK.
This study reports that hairy and enhancer of split homolog-1 (HES1), known to repress gene transcription in progenitor cells of several cell lineages, was strongly expressed in cells and tissues of T-cell lymphoma expressing the oncogenic chimeric tyrosine kinase nucleophosmin (NPM)-anaplastic lymphoma kinase [ALK; ALK+ T-cell lymphoma (TCL)]. The structural analysis of the Orange domain of HES1 indicated that HES1 ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID