BAIT
HDLBP
HBP, PRO2900, VGL
high density lipoprotein binding protein
GO Process (0)
GO Function (3)
GO Component (2)
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
WFS1
CTRCT41, WFRS, WFS, WFSL
Wolfram syndrome 1 (wolframin)
GO Process (27)
GO Function (4)
GO Component (4)
Gene Ontology Biological Process
- ER overload response [IC, TAS]
- ER-associated ubiquitin-dependent protein catabolic process [ISS]
- activation of signaling protein activity involved in unfolded protein response [TAS]
- calcium ion homeostasis [IDA]
- cellular protein metabolic process [TAS]
- endoplasmic reticulum calcium ion homeostasis [IDA]
- endoplasmic reticulum unfolded protein response [ISS, TAS]
- glucose homeostasis [IMP]
- kidney development [IMP]
- negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [ISS]
- negative regulation of neuron apoptotic process [IMP]
- negative regulation of programmed cell death [IMP]
- negative regulation of sequence-specific DNA binding transcription factor activity [ISS]
- negative regulation of type B pancreatic cell apoptotic process [IMP]
- neurological system process [IMP]
- polyubiquitinated misfolded protein transport [ISS]
- positive regulation of calcium ion transport [IDA]
- positive regulation of growth [ISS]
- positive regulation of protein metabolic process [IDA]
- positive regulation of protein ubiquitination [ISS]
- positive regulation of proteolysis [ISS]
- protein maturation by protein folding [IC]
- protein stabilization [ISS]
- renal water homeostasis [IMP]
- response to endoplasmic reticulum stress [IDA]
- sensory perception of sound [IMP]
- visual perception [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.
The contribution of abnormal metabolic targets to hepatocellular carcinoma (HCC) progression and the associated regulatory mechanisms are attractive research areas. High-density lipoprotein binding protein (HDLBP) is an important transporter that protects cells from excessive cholesterol accumulation, but few studies have identified a role for HDLBP in HCC progression.HDLBP expression was determined in HCC tissues and published datasets. The biological roles ... [more]
Cell Mol Gastroenterol Hepatol Oct. 17, 2022; 15(2);307-325 [Pubmed: 36244648]
Throughput
- Low Throughput
Curated By
- BioGRID