BAIT
HDLBP
HBP, PRO2900, VGL
high density lipoprotein binding protein
GO Process (0)
GO Function (3)
GO Component (2)
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
DKK1
DKK-1, SK, UNQ492/PRO1008
dickkopf WNT signaling pathway inhibitor 1
GO Process (13)
GO Function (5)
GO Component (2)
Gene Ontology Biological Process
- extracellular negative regulation of signal transduction [IDA]
- negative regulation of Wnt signaling pathway [IDA]
- negative regulation of canonical Wnt signaling pathway [IDA, IGI]
- negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment [IDA]
- negative regulation of cardiac muscle cell differentiation [IDA]
- negative regulation of mesodermal cell fate specification [IDA]
- negative regulation of pathway-restricted SMAD protein phosphorylation [IDA]
- negative regulation of peptidyl-serine phosphorylation [IDA]
- negative regulation of protein complex assembly [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA, ISS]
- positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway [ISS]
- regulation of endodermal cell fate specification [IDA]
- regulation of receptor internalization [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.
The contribution of abnormal metabolic targets to hepatocellular carcinoma (HCC) progression and the associated regulatory mechanisms are attractive research areas. High-density lipoprotein binding protein (HDLBP) is an important transporter that protects cells from excessive cholesterol accumulation, but few studies have identified a role for HDLBP in HCC progression.HDLBP expression was determined in HCC tissues and published datasets. The biological roles ... [more]
Cell Mol Gastroenterol Hepatol Oct. 17, 2022; 15(2);307-325 [Pubmed: 36244648]
Throughput
- Low Throughput
Curated By
- BioGRID