PAT1
Gene Ontology Biological Process
- CENP-A containing chromatin organization [IMP]
- chromosome segregation [IMP]
- cytoplasmic mRNA processing body assembly [IGI, IMP]
- deadenylation-dependent decapping of nuclear-transcribed mRNA [IMP, IPI]
- formation of translation preinitiation complex [IMP]
- negative regulation of translational initiation [IDA, IMP]
- regulation of translational initiation [IGI, IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
DED1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Synthetic Growth Defect
A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.
Publication
The DEAD-box RNA helicase Ded1p affects and accumulates in Saccharomyces cerevisiae P-bodies.
Recent results suggest that cytoplasmic mRNAs can form translationally repressed messenger ribonucleoprotein particles (mRNPs) capable of decapping and degradation, or accumulation into cytoplasmic processing bodies (P-bodies), which can function as sites of mRNA storage. The proteins that function in transitions between the translationally repressed mRNPs that accumulate in P-bodies and mRNPs engaged in translation are largely unknown. Herein, we demonstrate ... [more]
Throughput
- Low Throughput
Ontology Terms
- vegetative growth (APO:0000106)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PAT1 DED1 | Affinity Capture-RNA Affinity Capture-RNA An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and associated RNA species identified by Northern blot, RT-PCR, affinity labeling, sequencing, or microarray analysis. | High | - | BioGRID | 812792 | |
| DED1 PAT1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.3143 | BioGRID | 2017451 | |
| PAT1 DED1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.2074 | BioGRID | 2031585 |
Curated By
- BioGRID