BAIT
HDLBP
HBP, PRO2900, VGL
high density lipoprotein binding protein
GO Process (0)
GO Function (3)
GO Component (2)
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
VIL1
D2S1471, VIL
villin 1
GO Process (17)
GO Function (8)
GO Component (7)
Gene Ontology Biological Process
- actin filament capping [IDA]
- actin filament depolymerization [IDA]
- actin filament polymerization [IDA]
- actin filament severing [IDA]
- cellular response to epidermal growth factor stimulus [IDA]
- cytoplasmic actin-based contraction involved in cell motility [IDA]
- epidermal growth factor receptor signaling pathway [IDA]
- epithelial cell differentiation [IEP]
- positive regulation of actin filament bundle assembly [IDA]
- positive regulation of cell migration [IDA]
- positive regulation of epithelial cell migration [IDA]
- protein complex assembly [TAS]
- regulation of actin nucleation [IDA]
- regulation of cell shape [IDA]
- regulation of lamellipodium morphogenesis [ISS]
- regulation of wound healing [ISS]
- response to bacterium [IDA]
Gene Ontology Molecular Function- actin filament binding [IDA]
- calcium ion binding [IDA]
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process [ISS]
- identical protein binding [IPI]
- lysophosphatidic acid binding [IDA]
- phosphatidylinositol-4,5-bisphosphate binding [IDA]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- actin filament binding [IDA]
- calcium ion binding [IDA]
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process [ISS]
- identical protein binding [IPI]
- lysophosphatidic acid binding [IDA]
- phosphatidylinositol-4,5-bisphosphate binding [IDA]
- protein binding [IPI]
- protein homodimerization activity [IDA]
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.
The contribution of abnormal metabolic targets to hepatocellular carcinoma (HCC) progression and the associated regulatory mechanisms are attractive research areas. High-density lipoprotein binding protein (HDLBP) is an important transporter that protects cells from excessive cholesterol accumulation, but few studies have identified a role for HDLBP in HCC progression.HDLBP expression was determined in HCC tissues and published datasets. The biological roles ... [more]
Cell Mol Gastroenterol Hepatol Oct. 17, 2022; 15(2);307-325 [Pubmed: 36244648]
Throughput
- Low Throughput
Curated By
- BioGRID