BAIT
RAF1
CMD1NN, CRAF, NS5, Raf-1, c-Raf
Raf-1 proto-oncogene, serine/threonine kinase
GO Process (30)
GO Function (5)
GO Component (5)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- MAPK cascade [TAS]
- Ras protein signal transduction [TAS]
- activation of MAPKK activity [IDA, TAS]
- activation of adenylate cyclase activity [NAS]
- apoptotic process [TAS]
- axon guidance [TAS]
- blood coagulation [TAS]
- cell proliferation [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- insulin receptor signaling pathway [TAS]
- ion transmembrane transport [TAS]
- negative regulation of apoptotic process [IDA]
- negative regulation of cell proliferation [IDA]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [TAS]
- negative regulation of protein complex assembly [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- platelet activation [TAS]
- positive regulation of peptidyl-serine phosphorylation [IDA]
- regulation of Rho protein signal transduction [TAS]
- regulation of apoptotic process [TAS]
- regulation of cell differentiation [TAS]
- regulation of cell motility [TAS]
- signal transduction [TAS]
- small GTPase mediated signal transduction [TAS]
- synaptic transmission [TAS]
- transmembrane transport [TAS]
- wound healing [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
FXR2
FMR1L2, FXR2P
fragile X mental retardation, autosomal homolog 2
GO Process (1)
GO Function (5)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.
The contribution of abnormal metabolic targets to hepatocellular carcinoma (HCC) progression and the associated regulatory mechanisms are attractive research areas. High-density lipoprotein binding protein (HDLBP) is an important transporter that protects cells from excessive cholesterol accumulation, but few studies have identified a role for HDLBP in HCC progression.HDLBP expression was determined in HCC tissues and published datasets. The biological roles ... [more]
Cell Mol Gastroenterol Hepatol Oct. 17, 2022; 15(2);307-325 [Pubmed: 36244648]
Throughput
- Low Throughput
Curated By
- BioGRID